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Open AccessArticle

Clinicopathological Correlates of γδ T Cell Infiltration in Triple-Negative Breast Cancer

1
Institut Régional du Cancer de Montpellier (ICM), Val d’Aurelle, 34298 Montpellier, France
2
Institut de Recherche en Cancérologie de Montpellier (IRCM), Inserm U1194, 34298 Montpellier, France
3
Montpellier University, 34090 Montpellier, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Academic Editor: Rudolf Oehler
Cancers 2021, 13(4), 765; https://doi.org/10.3390/cancers13040765
Received: 20 January 2021 / Accepted: 8 February 2021 / Published: 12 February 2021
(This article belongs to the Special Issue Tumor Innate Immune Surveillance)
The prognostic impact of the different tumor-infiltrating lymphocyte (TIL) subpopulations remains debated in solid cancers. We investigated the clinicopathological correlates and prognostic impact of TILs, particularly of γδ T cells, in 162 triple-negative breast cancer (TNBC) patients. A high γδ T cell density was significantly associated with younger age, higher tumor histological grade, adjuvant chemotherapy, BRCA1 promoter methylation, TIL density, and PD-L1 and PD-1 expression. In multivariate analyses, γδ T cell infiltration was an independent prognostic factor. However, this prognostic impact varied according to the tumor PIK3CA mutational status. High γδ T cell infiltration was associated with better survival in patients with PIK3CA wild-type tumors, without significant difference in the PIK3CA-mutated tumor subgroup. Altogether, these data suggest that high γδ T cell infiltrate is correlated with immune infiltration and might represent a prognostic tool in TNBC patients.
The prognostic impact of the different tumor-infiltrating lymphocyte (TIL) subpopulations in solid cancers is still debated. Here, we investigated the clinicopathological correlates and prognostic impact of TILs, particularly of γδ T cells, in 162 patients with triple-negative breast cancer (TNBC). A high γδ T cell density (>6.625 γδ T cells/mm2) was associated with younger age (p = 0.008), higher tumor histological grade (p = 0.002), adjuvant chemotherapy (p = 0.010), BRCA1 promoter methylation (p = 0.010), TIL density (p < 0.001), and PD-L1 (p < 0.001) and PD-1 expression (p = 0.040). In multivariate analyses, γδ T cell infiltration (cutoff = 6.625 γδ T cells/mm2) was an independent prognostic factor (5-year relapse-free survival: 63.3% vs. 89.8%, p = 0.027; 5-year overall survival: 73.8% vs. 89.9%, p = 0.031, for low vs. high infiltration). This prognostic impact varied according to the tumor PIK3CA mutational status. High γδ T cell infiltration was associated with better survival in patients with PIK3CA wild-type tumors, but the difference was not significant in the subgroup with PIK3CA-mutated tumors. Altogether, these data suggest that high γδ T cell infiltrate is correlated with immune infiltration and might represent a candidate prognostic tool in patients with TNBC. View Full-Text
Keywords: triple-negative breast cancer; γδ T cells; prognosis; basal-like; BRCA1; PIK3CA triple-negative breast cancer; γδ T cells; prognosis; basal-like; BRCA1; PIK3CA
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MDPI and ACS Style

Boissière-Michot, F.; Chabab, G.; Mollevi, C.; Guiu, S.; Lopez-Crapez, E.; Ramos, J.; Bonnefoy, N.; Lafont, V.; Jacot, W. Clinicopathological Correlates of γδ T Cell Infiltration in Triple-Negative Breast Cancer. Cancers 2021, 13, 765. https://doi.org/10.3390/cancers13040765

AMA Style

Boissière-Michot F, Chabab G, Mollevi C, Guiu S, Lopez-Crapez E, Ramos J, Bonnefoy N, Lafont V, Jacot W. Clinicopathological Correlates of γδ T Cell Infiltration in Triple-Negative Breast Cancer. Cancers. 2021; 13(4):765. https://doi.org/10.3390/cancers13040765

Chicago/Turabian Style

Boissière-Michot, Florence; Chabab, Ghita; Mollevi, Caroline; Guiu, Séverine; Lopez-Crapez, Evelyne; Ramos, Jeanne; Bonnefoy, Nathalie; Lafont, Virginie; Jacot, William. 2021. "Clinicopathological Correlates of γδ T Cell Infiltration in Triple-Negative Breast Cancer" Cancers 13, no. 4: 765. https://doi.org/10.3390/cancers13040765

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