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Article

DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice

1
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St, 16/10, 117997 Moscow, Russia
2
MEPhI (Moscow Engineering Physics Institute), Institute of Engineering Physics for Biomedicine (PhysBio), 31 Kashirskoe Shosse, 115409 Moscow, Russia
3
Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St, 119991 Moscow, Russia
4
Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences and the Center of Nanoscience and Nanotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
*
Authors to whom correspondence should be addressed.
These authors equally contributed to this work.
Academic Editors: Dmitry Pshezhetskiy and Manfred Ogris
Cancers 2021, 13(20), 5235; https://doi.org/10.3390/cancers13205235
Received: 30 August 2021 / Revised: 21 September 2021 / Accepted: 15 October 2021 / Published: 19 October 2021
(This article belongs to the Section Cancer Therapy)
Breast cancer is one of the main causes of cancer-related death in women all around the world. The disease becomes largely incurable and lethal after metastasis to distant organs. High level of HER2, a tyrosine kinase receptor, is associated with more aggressive clinical behavior and poor prognosis for breast cancer patients. In this paper, we developed a novel nano-biomaterial for selective photothermal therapy of HER2-positive breast cancers. We demonstrate that bovine serum albumin (BSA)-coated mini gold nanorods (GNRs) chemically conjugated with a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light.
Near-infrared phototherapy has great therapeutic potential for cancer treatment. However, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer. View Full-Text
Keywords: cancer; DARPin; gold nanorods; mice treatment; near-infrared illumination; photothermal therapy cancer; DARPin; gold nanorods; mice treatment; near-infrared illumination; photothermal therapy
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MDPI and ACS Style

Proshkina, G.M.; Shramova, E.I.; Shilova, M.V.; Zelepukin, I.V.; Shipunova, V.O.; Ryabova, A.V.; Deyev, S.M.; Kotlyar, A.B. DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice. Cancers 2021, 13, 5235. https://doi.org/10.3390/cancers13205235

AMA Style

Proshkina GM, Shramova EI, Shilova MV, Zelepukin IV, Shipunova VO, Ryabova AV, Deyev SM, Kotlyar AB. DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice. Cancers. 2021; 13(20):5235. https://doi.org/10.3390/cancers13205235

Chicago/Turabian Style

Proshkina, Galina M., Elena I. Shramova, Marya V. Shilova, Ivan V. Zelepukin, Victoria O. Shipunova, Anastasia V. Ryabova, Sergey M. Deyev, and Alexander B. Kotlyar. 2021. "DARPin_9-29-Targeted Gold Nanorods Selectively Suppress HER2-Positive Tumor Growth in Mice" Cancers 13, no. 20: 5235. https://doi.org/10.3390/cancers13205235

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