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Neural Mechanisms of Cancer Cachexia
Article

MRI-Determined Psoas Muscle Fat Infiltration Correlates with Severity of Weight Loss during Cancer Cachexia

1
Department of Diagnostic and Interventional Radiology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany
2
Department of Surgery, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany
3
Institute for Diabetes and Cancer, Helmholtz Center Munich, 85764 Neuherberg, Germany
4
Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, 69120 Heidelberg, Germany
5
Chair Molecular Metabolic Control, Technical University Munich, 81675 Munich, Germany
6
Deutsches Zentrum für Diabetesforschung, 85764 Neuherberg, Germany
*
Author to whom correspondence should be addressed.
Lisa Patzelt and Daniela Junker contributed equally to this work.
Academic Editor: Jeffrey A. Borgia
Cancers 2021, 13(17), 4433; https://doi.org/10.3390/cancers13174433
Received: 12 August 2021 / Revised: 29 August 2021 / Accepted: 30 August 2021 / Published: 2 September 2021
(This article belongs to the Special Issue Cancer-Associated Cachexia)
During cancer cachexia, patients experience profound weight loss due to metabolic dysfunction, resulting in muscle composition alterations. The proton density fat fraction (PDFF) using magnetic resonance imaging (MRI) is an established biomarker to assess changes of muscle composition. We evaluated the suitability of MRI-determined psoas and erector spinae muscle PDFF and fat volume as biomarkers for monitoring cachexia development in an oncological cohort of 58 patients and assessed the regional variation in muscle parameters over time. Our results indicate that psoas muscle PDFF and fat volume could serve as MRI-determined biomarkers for early risk stratification and disease monitoring regarding progression and severity of weight loss in cancer cachexia.
Purpose: To evaluate the suitability of psoas and erector spinae muscle proton density fat fraction (PDFF) and fat volume as biomarkers for monitoring cachexia severity in an oncological cohort, and to evaluate regional variances in muscle parameters over time. Methods: In this prospective study, 58 oncological patients were examined by a 3 T MRI receiving between one and five scans. Muscle volume and PDFF were measured, segmentation masks were divided into proximal, middle and distal muscle section. Results: A regional variation of fat distribution in erector spinae muscle at baseline was found (p < 0.01). During follow-ups significant relative change of muscle parameters was observed. Relative maximum change of erector spinae muscle showed a significant regional variation. Correlation testing with age as a covariate revealed significant correlations for baseline psoas fat volume (r = −0.55, p < 0.01) and baseline psoas PDFF (r = −0.52, p = 0.02) with maximum BMI change during the course of the disease. Conclusion: In erector spinae muscles, a regional variation of fat distribution at baseline and relative maximum change of muscle parameters was observed. Our results indicate that psoas muscle PDFF and fat volume could serve as MRI-determined biomarkers for early risk stratification and disease monitoring regarding progression and severity of weight loss in cancer cachexia. View Full-Text
Keywords: magnetic resonance imaging; cancer cachexia; weight loss; skeletal muscle; proton density fat fraction (PDFF) magnetic resonance imaging; cancer cachexia; weight loss; skeletal muscle; proton density fat fraction (PDFF)
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MDPI and ACS Style

Patzelt, L.; Junker, D.; Syväri, J.; Burian, E.; Wu, M.; Prokopchuk, O.; Nitsche, U.; Makowski, M.R.; Braren, R.F.; Herzig, S.; Diaz, M.B.; Karampinos, D.C. MRI-Determined Psoas Muscle Fat Infiltration Correlates with Severity of Weight Loss during Cancer Cachexia. Cancers 2021, 13, 4433. https://doi.org/10.3390/cancers13174433

AMA Style

Patzelt L, Junker D, Syväri J, Burian E, Wu M, Prokopchuk O, Nitsche U, Makowski MR, Braren RF, Herzig S, Diaz MB, Karampinos DC. MRI-Determined Psoas Muscle Fat Infiltration Correlates with Severity of Weight Loss during Cancer Cachexia. Cancers. 2021; 13(17):4433. https://doi.org/10.3390/cancers13174433

Chicago/Turabian Style

Patzelt, Lisa, Daniela Junker, Jan Syväri, Egon Burian, Mingming Wu, Olga Prokopchuk, Ulrich Nitsche, Marcus R. Makowski, Rickmer F. Braren, Stephan Herzig, Mauricio B. Diaz, and Dimitrios C. Karampinos. 2021. "MRI-Determined Psoas Muscle Fat Infiltration Correlates with Severity of Weight Loss during Cancer Cachexia" Cancers 13, no. 17: 4433. https://doi.org/10.3390/cancers13174433

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