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Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy

Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2280 Inwood Road, Dallas, TX 75235, USA
Yantai Yuhuangding Hospital, Yantai 264000, China
Authors to whom correspondence should be addressed.
Cancers 2021, 13(1), 77;
Received: 17 November 2020 / Revised: 15 December 2020 / Accepted: 17 December 2020 / Published: 30 December 2020
(This article belongs to the Special Issue Challenges and Opportunities for Effective Cancer Immunotherapies)
Cancer immunotherapy is a breakthrough in cancer treatment. Unfortunately, despite the encouraging results in clinical treatment, cancer immunotherapy such as CAR-T, PD-1 still faces lots of challenges. Therefore, it is necessary to develop new methods to improve the effectiveness and safety of tumor immunotherapy. In recent years, cell membrane-coated nanomaterial is one of the most promising drug delivery systems and is receiving a great deal of attention due to its naturally biocompatible characteristics. This review summarizes the latest research progress, the advantages, the disadvantages, and the application of immunocyte membrane-coated nanoparticles in cancer immunotherapy.
Despite the advances in surface bioconjugation of synthetic nanoparticles for targeted drug delivery, simple biological functionalization is still insufficient to replicate complex intercellular interactions naturally. Therefore, these foreign nanoparticles are inevitably exposed to the immune system, which results in phagocytosis by the reticuloendothelial system and thus, loss of their biological significance. Immunocyte membranes play a key role in intercellular interactions, and can protect foreign nanomaterials as a natural barrier. Therefore, biomimetic nanotechnology based on cell membranes has developed rapidly in recent years. This paper summarizes the development of immunocyte membrane-coated nanoparticles in the immunotherapy of tumors. We will introduce several immunocyte membrane-coated nanocarriers and review the challenges to their large-scale preparation and application. View Full-Text
Keywords: immunocyte membrane-coated nanoparticles; biomimicry; cancer immunotherapy; macrophage; T-cell; natural killer; dendritic cell immunocyte membrane-coated nanoparticles; biomimicry; cancer immunotherapy; macrophage; T-cell; natural killer; dendritic cell
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MDPI and ACS Style

Gong, P.; Wang, Y.; Zhang, P.; Yang, Z.; Deng, W.; Sun, Z.; Yang, M.; Li, X.; Ma, G.; Deng, G.; Dong, S.; Cai, L.; Jiang, W. Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy. Cancers 2021, 13, 77.

AMA Style

Gong P, Wang Y, Zhang P, Yang Z, Deng W, Sun Z, Yang M, Li X, Ma G, Deng G, Dong S, Cai L, Jiang W. Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy. Cancers. 2021; 13(1):77.

Chicago/Turabian Style

Gong, Ping, Yifan Wang, Pengfei Zhang, Zhaogang Yang, Weiye Deng, Zhihong Sun, Mingming Yang, Xuefeng Li, Gongcheng Ma, Guanjun Deng, Shiyan Dong, Lintao Cai, and Wen Jiang. 2021. "Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy" Cancers 13, no. 1: 77.

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