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Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran
Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand 9717853577, Iran
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran 19839-63113, Iran
Authors to whom correspondence should be addressed.
Cancers 2020, 12(8), 2162;
Received: 29 May 2020 / Revised: 24 July 2020 / Accepted: 27 July 2020 / Published: 4 August 2020
Estrogen receptors (ERs) comprise several nuclear and membrane-bound receptors with different tissue-specific functions. ERα and ERβ are two nuclear members of this family, whereas G protein-coupled estrogen receptor (GPER), ER-X, and Gq-coupled membrane estrogen receptor (Gq-mER) are membrane-bound G protein-coupled proteins. ERα participates in the development and function of several body organs such as the reproductive system, brain, heart and musculoskeletal systems. ERβ has a highly tissue-specific expression pattern, particularly in the female reproductive system, and exerts tumor-suppressive roles in some tissues. Recent studies have revealed functional links between both nuclear and membrane-bound ERs and non-coding RNAs. Several oncogenic lncRNAs and miRNAs have been shown to exert their effects through the modulation of the expression of ERs. Moreover, treatment with estradiol has been shown to alter the malignant behavior of cancer cells through functional axes composed of non-coding RNAs and ERs. The interaction between ERs and non-coding RNAs has functional relevance in several human pathologies associated with estrogen regulation, such as cancers, intervertebral disc degeneration, coronary heart disease and diabetes. In the current review, we summarize scientific literature on the role of miRNAs and lncRNAs on ER-associated signaling and related disorders. View Full-Text
Keywords: lncRNA; miRNA; estrogen receptor; cancer lncRNA; miRNA; estrogen receptor; cancer
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Taheri, M.; Shoorei, H.; Dinger, M.E.; Ghafouri-Fard, S. Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor. Cancers 2020, 12, 2162.

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