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Single-Cell Heterogeneity of Cutaneous T-Cell Lymphomas Revealed Using RNA-Seq Technologies

Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznań, Poland
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Cancers 2020, 12(8), 2129; https://doi.org/10.3390/cancers12082129
Received: 22 June 2020 / Revised: 16 July 2020 / Accepted: 29 July 2020 / Published: 31 July 2020
Cutaneous T-cell lymphomas (CTCLs) represent a large, heterogeneous group of non-Hodgkin lymphomas that primarily affect the skin. Among multiple CTCL variants, the most prevalent types are mycosis fungoides (MF) and Sézary syndrome (SS). In the past decade, the molecular genetics of CTCL have been the target of intense study, increasing the knowledge of CTCL genomic alterations, discovering novel biomarkers, and potential targets for patient-specific therapy. However, the detailed pathogenesis of CTCL development still needs to be discovered. This review aims to summarize the novel insights into molecular heterogeneity of malignant cells using high-throughput technologies, such as RNA sequencing and single-cell RNA sequencing, which might be useful to identify tumour-specific molecular signatures and, therefore, offer guidance for therapy, diagnosis, and prognosis of CTCL. View Full-Text
Keywords: Sézary syndrome; mycosis fungoides; cutaneous T-cell lymphomas; single-cell heterogeneity; RNA-sequencing Sézary syndrome; mycosis fungoides; cutaneous T-cell lymphomas; single-cell heterogeneity; RNA-sequencing
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MDPI and ACS Style

Rassek, K.; Iżykowska, K. Single-Cell Heterogeneity of Cutaneous T-Cell Lymphomas Revealed Using RNA-Seq Technologies. Cancers 2020, 12, 2129. https://doi.org/10.3390/cancers12082129

AMA Style

Rassek K, Iżykowska K. Single-Cell Heterogeneity of Cutaneous T-Cell Lymphomas Revealed Using RNA-Seq Technologies. Cancers. 2020; 12(8):2129. https://doi.org/10.3390/cancers12082129

Chicago/Turabian Style

Rassek, Karolina, and Katarzyna Iżykowska. 2020. "Single-Cell Heterogeneity of Cutaneous T-Cell Lymphomas Revealed Using RNA-Seq Technologies" Cancers 12, no. 8: 2129. https://doi.org/10.3390/cancers12082129

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