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Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates

1
Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia
2
Laboratory for Protein Dynamics, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia
3
Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9PT, UK
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(7), 1910; https://doi.org/10.3390/cancers12071910
Received: 22 June 2020 / Revised: 10 July 2020 / Accepted: 12 July 2020 / Published: 15 July 2020
(This article belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)
Integrins are heterodimeric cell surface receptors composed of α and β subunits that control adhesion, proliferation and gene expression. The integrin heterodimer binding to ligand reorganises the cytoskeletal networks and triggers multiple signalling pathways that can cause changes in cell cycle, proliferation, differentiation, survival and motility. In addition, integrins have been identified as targets for many different diseases, including cancer. Integrin crosstalk is a mechanism by which a change in the expression of a certain integrin subunit or the activation of an integrin heterodimer may interfere with the expression and/or activation of other integrin subunit(s) in the very same cell. Here, we review the evidence for integrin crosstalk in a range of cellular systems, with a particular emphasis on cancer. We describe the molecular mechanisms of integrin crosstalk, the effects of cell fate determination, and the contribution of crosstalk to therapeutic outcomes. Our intention is to raise awareness of integrin crosstalk events such that the contribution of the phenomenon can be taken into account when researching the biological or pathophysiological roles of integrins. View Full-Text
Keywords: integrin; integrin adhesion complexes; integrin crosstalk; integrin switching; cancer integrin; integrin adhesion complexes; integrin crosstalk; integrin switching; cancer
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MDPI and ACS Style

Samaržija, I.; Dekanić, A.; Humphries, J.D.; Paradžik, M.; Stojanović, N.; Humphries, M.J.; Ambriović-Ristov, A. Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates. Cancers 2020, 12, 1910. https://doi.org/10.3390/cancers12071910

AMA Style

Samaržija I, Dekanić A, Humphries JD, Paradžik M, Stojanović N, Humphries MJ, Ambriović-Ristov A. Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates. Cancers. 2020; 12(7):1910. https://doi.org/10.3390/cancers12071910

Chicago/Turabian Style

Samaržija, Ivana, Ana Dekanić, Jonathan D. Humphries, Mladen Paradžik, Nikolina Stojanović, Martin J. Humphries, and Andreja Ambriović-Ristov. 2020. "Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates" Cancers 12, no. 7: 1910. https://doi.org/10.3390/cancers12071910

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