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The Cancer Stem Cell in Hepatocellular Carcinoma
Open AccessArticle

Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma

by 1,2,3,4,†, 5,6,†, 7,†, 8 and 8,*
1
Department of Pathology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
2
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan
3
Department of Health Food, Chung Chou University of Science and Technology, Changhua 500, Taiwan
4
National Institute of Cancer Research, National Health Research Institute, Tainan 704, Taiwan
5
Department of Hematology and Oncology, Ton-Yen General Hospital, Hsinchu 302, Taiwan
6
Department of Nursing, Hsin Sheng Junior College of Medical Care and Management, Taoyuan City 325, Taiwan
7
Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 235, Taiwan
8
Graduate Institute of Integrated Medicine, China Medical University, No.91, Hsueh-Shih Road, Taichung 40402, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(7), 1843; https://doi.org/10.3390/cancers12071843
Received: 28 June 2020 / Accepted: 6 July 2020 / Published: 8 July 2020
(This article belongs to the Special Issue Liver Cancer and Potential Therapeutic Targets)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide, affecting over 700,000 people per year. The treatment effect in advanced HCC is still disappointing and prognosis of advanced HCC remains poor. Hence, to find more effective therapeutic targets to improve the treatment outcome of HCC is of urgent need. In this study, we reported the novel oncogenic function of SAAL1 (serum amyloid A-like 1) in HCC, which previously is considered as an inflammation-related gene. We found that SAAL1 was significantly upregulated in HCC tumor tissues when compared to the adjacent normal tissues and high expression of SAAL1 correlated with shorter overall survival in The Cancer Genome Atlas (TCGA) HCC database. Functionally, we showed that the depletion of SAAL1 significantly reduced cell proliferation, 3D colony formation, and migration/invasion abilities of HCC cancer cells. Furthermore, suppression of SAAL1 impaired the HGF/Met-driven Akt/mTOR phosphorylation cascade and increased the chemosensitivity of HCC cells to sorafenib and foretinib treatment. Our data indicated that SAAL1 plays an important role in HCC via mediating oncogenic HGF/Met-driven Akt/mTOR signaling and could serve as an independent prognostic marker, as well as a promising therapeutic target for HCC patients. View Full-Text
Keywords: HCC; SAAL1; HGF; Met HCC; SAAL1; HGF; Met
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MDPI and ACS Style

Chu, P.-Y.; Tung, S.-L.; Tsai, K.-W.; Shen, F.-P.; Chan, S.-H. Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma. Cancers 2020, 12, 1843. https://doi.org/10.3390/cancers12071843

AMA Style

Chu P-Y, Tung S-L, Tsai K-W, Shen F-P, Chan S-H. Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma. Cancers. 2020; 12(7):1843. https://doi.org/10.3390/cancers12071843

Chicago/Turabian Style

Chu, Pei-Yi; Tung, Shiao-Lin; Tsai, Kuo-Wang; Shen, Fang-Ping; Chan, Shih-Hsuan. 2020. "Identification of the Novel Oncogenic Role of SAAL1 and Its Therapeutic Potential in Hepatocellular Carcinoma" Cancers 12, no. 7: 1843. https://doi.org/10.3390/cancers12071843

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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