Next Article in Journal
Enhancement of Breast Cancer Cell Aggressiveness by lncRNA H19 and its Mir-675 Derivative: Insight into Shared and Different Actions
Previous Article in Journal
Pimasertib Versus Dacarbazine in Patients With Unresectable NRAS-Mutated Cutaneous Melanoma: Phase II, Randomized, Controlled Trial with Crossover
Previous Article in Special Issue
Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up of Exocrine Pancreatic Ductal Adenocarcinoma: Evidence Evaluation and Recommendations by the Italian Association of Medical Oncology (AIOM)
Open AccessReview

Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines

1
Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radioterapia Oncologica, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, 00168 Roma, Italy
2
Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine—DIMES, University of Bologna, S. Orsola-Malpighi Hospital, 40138 Bologna, Italy
3
Radiotherapy Unit, Azienda Ospedaliera Universitaria, 37126 Verona, Italy
4
Department of Radiation Oncology, SS. Annunziata Hospital, "G. D’Annunzio" University, Via Dei Vestini, 66100 Chieti, Italy
5
Radiology Unit—IRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, Italy
6
Medical Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco, 65, 70124 Bari, Italy
7
Department of Neuroscience, Imaging and Clinical Sciences, “G. D’Annunzio” University, 66100 Chieti, Italy
8
Istituto di Radiologia, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
9
Radiotherapy Unit, Gemelli Molise Hospital, 86100 Campobasso, Italy
10
IRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, Italy
11
Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(7), 1729; https://doi.org/10.3390/cancers12071729 (registering DOI)
Received: 26 April 2020 / Revised: 11 June 2020 / Accepted: 17 June 2020 / Published: 29 June 2020
(This article belongs to the Special Issue Advances in Pancreatic Cancer Research)
Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation’s definitions as up-front resectable, borderline resectable and locally advanced (unresectable). The main treatment categories are neoadjuvant (preoperative), definitive and adjuvant (postoperative). This review will focus on (i) the current indications by the available national and international guidelines; (ii) the current standard indications for target volume delineation in radiotherapy (RT); (iii) the emerging modern technologies (including particle therapy and Magnetic Resonance [MR]-guided-RT); (iv) stereotactic body radiotherapy (SBRT), as the most promising technical delivery application of RT in this framework; (v) a particularly promising dose delivery technique called simultaneous integrated boost (SIB); and (vi) a multimodal integration opportunity: the combination of RT with immunotherapy. View Full-Text
Keywords: pancreatic cancer; radiotherapy; immunotherapy; SBRT; guidelines; review; CTV; MR guided RT; protons; SIB pancreatic cancer; radiotherapy; immunotherapy; SBRT; guidelines; review; CTV; MR guided RT; protons; SIB
Show Figures

Figure 1

MDPI and ACS Style

Cellini, F.; Arcelli, A.; Simoni, N.; Caravatta, L.; Buwenge, M.; Calabrese, A.; Brunetti, O.; Genovesi, D.; Mazzarotto, R.; Deodato, F.; Mattiucci, G.C.; Silvestris, N.; Valentini, V.; Morganti, A.G. Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines. Cancers 2020, 12, 1729.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop