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Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

Faculty of Medicine and Surgery—Vita-Salute San Raffaele University, 20132 Milan, Italy
Division of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
Department of Respiratory Medicine, David Evans Research Centre, Nottingham University Hospitals NHS Trust, Nottingham NG5 1PB, UK
Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Department of Social and Political Sciences, Bocconi University, 20136 Milan, Italy
Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority (INAIL), 00078 Rome, Italy
Center for Medical Imaging, University Medical Center Groningen, University of Groningen, 9712 CP Groningen, The Netherlands
Department of Public Health, Erasmus MC—University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands
The Grace Ballas Cardiac Research Unit, Sheba Medical Center, Affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, 52621 Tel Aviv-Yafo, Israel
Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool, Liverpool L69 3BX, UK
Department of Pulmonology, Clinica Universidad de Navarra, 31008 Pamplona, Spain
Visiongate Inc., Phoenix, AZ 85044, USA
European Alliance for Personalised Medicine (EAPM), Avenue de l’Armée Legerlaan 10, 1040 Brussels, Belgium
Thoracic Surgery Department, University and Hospital Trust—Ospedale Borgo Trento, 37126 Verona, Italy
Division of Epidemiology and Public Health, UK Centre for Tobacco and Alcohol Studies, Clinical Sciences Building, City Hospital, University of Nottingham, Nottingham NG5 1PB, UK
The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, 84101 Beer-Sheva, Israel
Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Department of Thoracic Surgery, Medical University of Gdańsk, 80-210 Gdańsk, Poland
Department of Oncology, University of Torino, 10124 Torino, Italy
Department of Health Sciences, Brock University, 1812 Sir Isaac Brock Way, St Catharines, ON L2S 3A1, Canada
Division of Thoracic Surgery, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy
Faculty of Medicine and Public Health, Chulabhorn Royal Academy, HRH Princess Chulabhorn College of Medical Science, Bangkok 10210, Thailand
Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele (MI), Italy
Department of Radiation Oncology, Amsterdam University Medical Centers, VU location, De Boelelaan 1117, Postbox 7057, 1007 MB Amsterdam, The Netherlands
Department of Cardiovascular Medicine, Humanitas Clinical and Research Center IRCCS, 20089 Rozzano (MI), Italy
Division of Population Medicine, School of Medicine, Cardiff University, Cardiff CF14 4YS, UK
Department of Bioimaging and Radiological Sciences, Catholic University, 00168 Rome, Italy
Epidemiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Thoracic Oncology, Antwerp University Hospital and Ghent University, 2650 Edegem, Belgium
Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy
Department of Radiology, Royal Brompton Hospital, London SW3 6NP, UK
Department of Respiratory Medicine, Herlev-Gentofte University Hospital, 2900 Hellerup, Denmark
Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy
Inter-Hospital Pathology Division, IRCCS MultiMedica, 20138 Milan, Italy
Author to whom correspondence should be addressed.
Cancers 2020, 12(6), 1672;
Received: 7 May 2020 / Revised: 15 June 2020 / Accepted: 17 June 2020 / Published: 24 June 2020
(This article belongs to the Special Issue Diagnostic and Predictive Biomarkers in Lung Cancer)
Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached. View Full-Text
Keywords: consensus; statement; screening; lung cancer; mortality; reduction; low dose; computed tomography; implementation consensus; statement; screening; lung cancer; mortality; reduction; low dose; computed tomography; implementation
MDPI and ACS Style

Veronesi, G.; Baldwin, D.R.; Henschke, C.I.; Ghislandi, S.; Iavicoli, S.; Oudkerk, M.; De Koning, H.J.; Shemesh, J.; Field, J.K.; Zulueta, J.J.; Horgan, D.; Fiestas Navarrete, L.; Infante, M.V.; Novellis, P.; Murray, R.L.; Peled, N.; Rampinelli, C.; Rocco, G.; Rzyman, W.; Scagliotti, G.V.; Tammemagi, M.C.; Bertolaccini, L.; Triphuridet, N.; Yip, R.; Rossi, A.; Senan, S.; Ferrante, G.; Brain, K.; van der Aalst, C.; Bonomo, L.; Consonni, D.; Van Meerbeeck, J.P.; Maisonneuve, P.; Novello, S.; Devaraj, A.; Saghir, Z.; Pelosi, G. Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe. Cancers 2020, 12, 1672.

AMA Style

Veronesi G, Baldwin DR, Henschke CI, Ghislandi S, Iavicoli S, Oudkerk M, De Koning HJ, Shemesh J, Field JK, Zulueta JJ, Horgan D, Fiestas Navarrete L, Infante MV, Novellis P, Murray RL, Peled N, Rampinelli C, Rocco G, Rzyman W, Scagliotti GV, Tammemagi MC, Bertolaccini L, Triphuridet N, Yip R, Rossi A, Senan S, Ferrante G, Brain K, van der Aalst C, Bonomo L, Consonni D, Van Meerbeeck JP, Maisonneuve P, Novello S, Devaraj A, Saghir Z, Pelosi G. Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe. Cancers. 2020; 12(6):1672.

Chicago/Turabian Style

Veronesi, Giulia, David R. Baldwin, Claudia I. Henschke, Simone Ghislandi, Sergio Iavicoli, Matthijs Oudkerk, Harry J. De Koning, Joseph Shemesh, John K. Field, Javier J. Zulueta, Denis Horgan, Lucia Fiestas Navarrete, Maurizio V. Infante, Pierluigi Novellis, Rachael L. Murray, Nir Peled, Cristiano Rampinelli, Gaetano Rocco, Witold Rzyman, Giorgio V. Scagliotti, Martin C. Tammemagi, Luca Bertolaccini, Natthaya Triphuridet, Rowena Yip, Alexia Rossi, Suresh Senan, Giuseppe Ferrante, Kate Brain, Carlijn van der Aalst, Lorenzo Bonomo, Dario Consonni, Jan P. Van Meerbeeck, Patrick Maisonneuve, Silvia Novello, Anand Devaraj, Zaigham Saghir, and Giuseppe Pelosi. 2020. "Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe" Cancers 12, no. 6: 1672.

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