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Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

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Faculty of Medicine and Surgery—Vita-Salute San Raffaele University, 20132 Milan, Italy
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Division of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
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Department of Respiratory Medicine, David Evans Research Centre, Nottingham University Hospitals NHS Trust, Nottingham NG5 1PB, UK
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Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
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Department of Social and Political Sciences, Bocconi University, 20136 Milan, Italy
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Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority (INAIL), 00078 Rome, Italy
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Center for Medical Imaging, University Medical Center Groningen, University of Groningen, 9712 CP Groningen, The Netherlands
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Department of Public Health, Erasmus MC—University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands
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The Grace Ballas Cardiac Research Unit, Sheba Medical Center, Affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, 52621 Tel Aviv-Yafo, Israel
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Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool, Liverpool L69 3BX, UK
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Department of Pulmonology, Clinica Universidad de Navarra, 31008 Pamplona, Spain
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Visiongate Inc., Phoenix, AZ 85044, USA
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European Alliance for Personalised Medicine (EAPM), Avenue de l’Armée Legerlaan 10, 1040 Brussels, Belgium
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Thoracic Surgery Department, University and Hospital Trust—Ospedale Borgo Trento, 37126 Verona, Italy
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Division of Epidemiology and Public Health, UK Centre for Tobacco and Alcohol Studies, Clinical Sciences Building, City Hospital, University of Nottingham, Nottingham NG5 1PB, UK
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The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, 84101 Beer-Sheva, Israel
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Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy
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Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
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Department of Thoracic Surgery, Medical University of Gdańsk, 80-210 Gdańsk, Poland
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Department of Oncology, University of Torino, 10124 Torino, Italy
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Department of Health Sciences, Brock University, 1812 Sir Isaac Brock Way, St Catharines, ON L2S 3A1, Canada
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Division of Thoracic Surgery, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy
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Faculty of Medicine and Public Health, Chulabhorn Royal Academy, HRH Princess Chulabhorn College of Medical Science, Bangkok 10210, Thailand
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Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele (MI), Italy
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Department of Radiation Oncology, Amsterdam University Medical Centers, VU location, De Boelelaan 1117, Postbox 7057, 1007 MB Amsterdam, The Netherlands
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Department of Cardiovascular Medicine, Humanitas Clinical and Research Center IRCCS, 20089 Rozzano (MI), Italy
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Division of Population Medicine, School of Medicine, Cardiff University, Cardiff CF14 4YS, UK
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Department of Bioimaging and Radiological Sciences, Catholic University, 00168 Rome, Italy
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Epidemiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
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Thoracic Oncology, Antwerp University Hospital and Ghent University, 2650 Edegem, Belgium
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Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy
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Department of Radiology, Royal Brompton Hospital, London SW3 6NP, UK
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Department of Respiratory Medicine, Herlev-Gentofte University Hospital, 2900 Hellerup, Denmark
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Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy
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Inter-Hospital Pathology Division, IRCCS MultiMedica, 20138 Milan, Italy
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Author to whom correspondence should be addressed.
Cancers 2020, 12(6), 1672; https://doi.org/10.3390/cancers12061672
Received: 7 May 2020 / Revised: 15 June 2020 / Accepted: 17 June 2020 / Published: 24 June 2020
(This article belongs to the Special Issue Diagnostic and Predictive Biomarkers in Lung Cancer)
Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached. View Full-Text
Keywords: consensus; statement; screening; lung cancer; mortality; reduction; low dose; computed tomography; implementation consensus; statement; screening; lung cancer; mortality; reduction; low dose; computed tomography; implementation
MDPI and ACS Style

Veronesi, G.; Baldwin, D.R.; Henschke, C.I.; Ghislandi, S.; Iavicoli, S.; Oudkerk, M.; De Koning, H.J.; Shemesh, J.; Field, J.K.; Zulueta, J.J.; Horgan, D.; Fiestas Navarrete, L.; Valentino Infante, M.; Novellis, P.; Murray, R.L.; Peled, N.; Rampinelli, C.; Rocco, G.; Rzyman, W.; Scagliotti, G.V.; Tammemagi, M.C.; Bertolaccini, L.; Triphuridet, N.; Yip, R.; Rossi, A.; Senan, S.; Ferrante, G.; Brain, K.; van der Aalst, C.; Bonomo, L.; Consonni, D.; Van Meerbeeck, J.P.; Maisonneuve, P.; Novello, S.; Devaraj, A.; Saghir, Z.; Pelosi, G. Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe. Cancers 2020, 12, 1672.

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