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Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target

College of Pharmacy, Dongguk University, Seoul 04620, Korea
Author to whom correspondence should be addressed.
Cancers 2020, 12(6), 1600;
Received: 2 April 2020 / Revised: 4 June 2020 / Accepted: 8 June 2020 / Published: 17 June 2020
(This article belongs to the Special Issue Novel Biomarkers and Molecular Targets in Cancer)
Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. Here, we gather evidence to determine the applicability of ANLN as a prognostic tool for some types of cancer, and the impact that ANLN has on the hallmarks of cancer. We searched academic repositories including PubMed and Google Scholar to find and review studies related to cancer and ANLN. The conclusion is that ANLN could be a potent target for cancer treatment, but the roles ANLN, other than in cytokinesis and its influence on tumour microenvironment remodeling in cancer development, must be further elucidated, and specific ANLN inhibitors should be found. View Full-Text
Keywords: anillin; cytokinesis; actin-binding protein; tumour microenvironments; inhibitors anillin; cytokinesis; actin-binding protein; tumour microenvironments; inhibitors
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Tuan, N.M.; Lee, C.H. Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target. Cancers 2020, 12, 1600.

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