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Perspective

MHC Class I Regulation: The Origin Perspective

International Center for Cancer Vaccine Science, University of Gdansk, 80-308 Gdansk, Poland
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(5), 1155; https://doi.org/10.3390/cancers12051155
Received: 10 February 2020 / Revised: 27 April 2020 / Accepted: 3 May 2020 / Published: 4 May 2020
(This article belongs to the Special Issue New Insights into Cancer Vaccines and Immunotherapy)
Viral-derived elements and non-coding RNAs that build up “junk DNA” allow for flexible and context-dependent gene expression. They are extremely dense in the MHC region, accounting for flexible expression of the MHC I, II, and III genes and adjusting the level of immune response to the environmental stimuli. This review brings forward the viral-mediated aspects of the origin and evolution of adaptive immunity and aims to link this perspective with the MHC class I regulation. The complex regulatory network behind MHC expression is largely controlled by virus-derived elements, both as binding sites for immune transcription factors and as sources of regulatory non-coding RNAs. These regulatory RNAs are imbalanced in cancer and associate with different tumor types, making them promising targets for diagnostic and therapeutic interventions. View Full-Text
Keywords: viruses in evolution; ERVs; HERVs; adaptive immunity; MHC class I; non-coding RNAs; miRNAs viruses in evolution; ERVs; HERVs; adaptive immunity; MHC class I; non-coding RNAs; miRNAs
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MDPI and ACS Style

Sznarkowska, A.; Mikac, S.; Pilch, M. MHC Class I Regulation: The Origin Perspective. Cancers 2020, 12, 1155. https://doi.org/10.3390/cancers12051155

AMA Style

Sznarkowska A, Mikac S, Pilch M. MHC Class I Regulation: The Origin Perspective. Cancers. 2020; 12(5):1155. https://doi.org/10.3390/cancers12051155

Chicago/Turabian Style

Sznarkowska, Alicja, Sara Mikac, and Magdalena Pilch. 2020. "MHC Class I Regulation: The Origin Perspective" Cancers 12, no. 5: 1155. https://doi.org/10.3390/cancers12051155

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