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Endogenously-Activated Ultrasmall-in-Nano Therapeutics: Assessment on 3D Head and Neck Squamous Cell Carcinomas

1
Center for Nanotechnology [email protected], Istituto Italiano di Tecnologia, Piazza San Silvestro, 12-56126 Pisa, Italy
2
NEST-Scuola Normale Superiore, Piazza San Silvestro, 12-56126 Pisa, Italy
*
Authors to whom correspondence should be addressed.
Cancers 2020, 12(5), 1063; https://doi.org/10.3390/cancers12051063
Received: 27 February 2020 / Revised: 22 April 2020 / Accepted: 22 April 2020 / Published: 25 April 2020
Negative or positive HPV-associated Head and Neck Squamous Cell Carcinomas (HNSCCs) are high recurrence neoplasms usually resulting in a poor prognosis, mainly due to metastasis formation. Despite the low overall patient survival rate and the severe side effects, the treatment of choice is still cisplatin-based chemotherapy. Here, we report a straightforward protocol for the production of high throughput 3D models of negative or positive HPV-associated HNSCCs, together with their employment in the therapeutic evaluation of gold ultrasmall-in-nano architectures comprising an endogenously-activatable cisplatin prodrug. Beyond enhancing the biosafety of cisplatin, our approach paves the way for the establishment of synergistic co-therapies for HNSCCs based on excretable noble metals. View Full-Text
Keywords: cancer; cisplatin; 3D models; nanomaterials; theranostics cancer; cisplatin; 3D models; nanomaterials; theranostics
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MDPI and ACS Style

Santi, M.; Mapanao, A.K.; Cassano, D.; Vlamidis, Y.; Cappello, V.; Voliani, V. Endogenously-Activated Ultrasmall-in-Nano Therapeutics: Assessment on 3D Head and Neck Squamous Cell Carcinomas. Cancers 2020, 12, 1063. https://doi.org/10.3390/cancers12051063

AMA Style

Santi M, Mapanao AK, Cassano D, Vlamidis Y, Cappello V, Voliani V. Endogenously-Activated Ultrasmall-in-Nano Therapeutics: Assessment on 3D Head and Neck Squamous Cell Carcinomas. Cancers. 2020; 12(5):1063. https://doi.org/10.3390/cancers12051063

Chicago/Turabian Style

Santi, Melissa, Ana K. Mapanao, Domenico Cassano, Ylea Vlamidis, Valentina Cappello, and Valerio Voliani. 2020. "Endogenously-Activated Ultrasmall-in-Nano Therapeutics: Assessment on 3D Head and Neck Squamous Cell Carcinomas" Cancers 12, no. 5: 1063. https://doi.org/10.3390/cancers12051063

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