Next Article in Journal
Effectiveness and Costs Associated to Adding Cetuximab or Bevacizumab to Chemotherapy as Initial Treatment in Metastatic Colorectal Cancer: Results from the Observational FABIO Project
Next Article in Special Issue
Natural Killer Cell Responses in Hepatocellular Carcinoma: Implications for Novel Immunotherapeutic Approaches
Previous Article in Journal
Immunomodulatory Molecules On Lung Cancer Stem Cells From Lymph Nodes Aspirates
Previous Article in Special Issue
NK and NKT Cell-Mediated Immune Surveillance against Hematological Malignancies
Open AccessReview

Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors

1
Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
2
Department of Medical and Surgical Sciences, University Magna Graecia, 88100 Catanzaro, Italy
3
Department of Clinical and Experimental Medicine, University Magna Graecia, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(4), 840; https://doi.org/10.3390/cancers12040840
Received: 13 February 2020 / Revised: 21 March 2020 / Accepted: 26 March 2020 / Published: 31 March 2020
(This article belongs to the Special Issue Targeting Innate Immunity Cells in Cancer)
In the adult, many embryologic processes can be co-opted by during cancer progression. The mechanisms of divisions, migration, and the ability to escape immunity recognition linked to specific embryo antigens are also expressed by malignant cells. In particular, cells derived from neural crests (NC) contribute to the development of multiple cell types including melanocytes, craniofacial cartilage, glia, neurons, peripheral and enteric nervous systems, and the adrenal medulla. This plastic performance is due to an accurate program of gene expression orchestrated with cellular/extracellular signals finalized to regulate long-distance migration, proliferation, differentiation, apoptosis, and survival. During neurulation, prior to initiating their migration, NC cells must undergo an epithelial–mesenchymal transition (EMT) in which they alter their actin cytoskeleton, lose their cell–cell junctions, apicobasal polarity, and acquire a motile phenotype. Similarly, during the development of the tumors derived from neural crests, comprising a heterogeneous group of neoplasms (Neural crest-derived tumors (NCDTs)), a group of genes responsible for the EMT pathway is activated. Here, retracing the molecular pathways performed by pluripotent cells at the boundary between neural and non-neural ectoderm in relation to the natural history of NCDT, points of contact or interposition are highlighted to better explain the intricate interplay between cancer cells and the innate and adaptive immune response. View Full-Text
Keywords: innate immunity; adaptive immunity; tumors neural crest-derived innate immunity; adaptive immunity; tumors neural crest-derived
Show Figures

Figure 1

MDPI and ACS Style

Donato, G.; Presta, I.; Arcidiacono, B.; Vismara, M.F.; Donato, A.; Garo, N.C.; Malara, N. Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors. Cancers 2020, 12, 840.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop