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Open AccessArticle

Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics

1
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, 18016 Granada, Spain
2
Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland
3
Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18016 Granada, Spain
4
Service of Medical Oncology, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain
5
Instituto Biosanitario de Granada (ibs. GRANADA), 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors are both co-senior authors.
Cancers 2020, 12(4), 1002; https://doi.org/10.3390/cancers12041002
Received: 25 March 2020 / Revised: 8 April 2020 / Accepted: 13 April 2020 / Published: 18 April 2020
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers, with a 5-year survival rate of less than 5%. In fact, complete surgical resection remains the only curative treatment. However, fewer than 20% of patients are candidates for surgery at the time of presentation. Hence, there is a critical need to identify diagnostic biomarkers with potential clinical utility in this pathology. In this context, metabolomics could be a powerful tool to search for new robust biomarkers. Comparative metabolomic profiling was performed in serum samples from 59 unresectable PDAC patients and 60 healthy controls. Samples were analyzed by using an untargeted metabolomics workflow based on liquid chromatography, coupled to high-resolution mass spectrometry in positive and negative electrospray ionization modes. Univariate and multivariate analysis allowed the identification of potential candidates that were significantly altered in PDAC patients. A panel of nine candidates yielded excellent diagnostic capacities. Pathway analysis revealed four altered pathways in our patients. This study shows the potential of liquid chromatography coupled to high-resolution mass spectrometry as a diagnostic tool for PDAC. Furthermore, it identified novel robust biomarkers with excellent diagnostic capacities. View Full-Text
Keywords: metabolomics; pancreatic ductal adenocarcinoma; reverse-phase liquid chromatography; biomarker; diagnosis metabolomics; pancreatic ductal adenocarcinoma; reverse-phase liquid chromatography; biomarker; diagnosis
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MDPI and ACS Style

Martín-Blázquez, A.; Jiménez-Luna, C.; Díaz, C.; Martínez-Galán, J.; Prados, J.; Vicente, F.; Melguizo, C.; Genilloud, O.; Pérez del Palacio, J.; Caba, O. Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics. Cancers 2020, 12, 1002. https://doi.org/10.3390/cancers12041002

AMA Style

Martín-Blázquez A, Jiménez-Luna C, Díaz C, Martínez-Galán J, Prados J, Vicente F, Melguizo C, Genilloud O, Pérez del Palacio J, Caba O. Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics. Cancers. 2020; 12(4):1002. https://doi.org/10.3390/cancers12041002

Chicago/Turabian Style

Martín-Blázquez, Ariadna; Jiménez-Luna, Cristina; Díaz, Caridad; Martínez-Galán, Joaquina; Prados, Jose; Vicente, Francisca; Melguizo, Consolación; Genilloud, Olga; Pérez del Palacio, José; Caba, Octavio. 2020. "Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics" Cancers 12, no. 4: 1002. https://doi.org/10.3390/cancers12041002

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