Cellular Functions of OCT-3/4 Regulated by Ubiquitination in Proliferating Cells
Abstract
:1. Introduction
2. Harmony between Ubiquitination and Deubiquitination Regulates Cellular Functions
3. OCT-3/4 Regulated by Several PTMs
4. Expression of OCT-3/4 in Different Cancer Cells
5. Differentiation of ESCs Induced by Ubiquitination of OCT-3/4
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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References | ||||
---|---|---|---|---|
OCT-3/4 | Cancer cells | Cell line | Cervical cancer | [3,56] |
Testicular germ cell tumor (TGCTs) | [4,5,57,66] | |||
Drug-resistant cells (prostate cancer) | [5,7,58,59,83] | |||
Undifferentiated tumor-initiating cells (TICs) | [7,57,79,80,81,82,83,84,85,86,87] | |||
Colon cancer | [7,61,89] | |||
Breast cancer | [1,63,89] | |||
Kinases | Phosphorylation: Serine 347 | [34] | ||
PTMs | Modified residues of OCT-3/4 | 1. Phosphorylation: Serine 347 | [34] | |
2. SUMOylation: Lysine 118 | [46,47] | |||
3. O-linked-N-acetylglucosamine (O-GlcNAc): Threonine 228 | [14] | |||
E3 ligases | WW domain-containing protein 2 (WWP2) | [49,50,51] | ||
Itchy E3 ubiquitin protein ligase (Itch) | [50,51] | |||
Carboxy terminus of HSP-70-interacting protein (CHIP) | [1] | |||
Double PHD fingers 2 (DPF2) | [36] | |||
Ring finger protein 2 (RNF2) | [73] | |||
F-box and WD repeat domain containing 8 (FBXW8) | [34] | |||
DUBs | Ubiquitin specific peptidase 44 (USP44) | [17,54,55] | ||
Ubiquitin specific peptidase 34 (USP34) | [52] | |||
Ubiquitin specific peptidase 7 (USP7) | [55] | |||
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) | [17] |
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Baek, K.-H.; Choi, J.; Pei, C.-Z. Cellular Functions of OCT-3/4 Regulated by Ubiquitination in Proliferating Cells. Cancers 2020, 12, 663. https://doi.org/10.3390/cancers12030663
Baek K-H, Choi J, Pei C-Z. Cellular Functions of OCT-3/4 Regulated by Ubiquitination in Proliferating Cells. Cancers. 2020; 12(3):663. https://doi.org/10.3390/cancers12030663
Chicago/Turabian StyleBaek, Kwang-Hyun, Jihye Choi, and Chang-Zhu Pei. 2020. "Cellular Functions of OCT-3/4 Regulated by Ubiquitination in Proliferating Cells" Cancers 12, no. 3: 663. https://doi.org/10.3390/cancers12030663