circ2GO: A Database Linking Circular RNAs to Gene Function
Department of Thoracic Surgery, Division of Cancer Research, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
German Cancer Consortium (DKTK), Partner Site Freiburg, 79106 Freiburg, Germany
Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Author to whom correspondence should be addressed.
Received: 21 September 2020
Revised: 10 October 2020
Accepted: 12 October 2020
Published: 14 October 2020
Ribonucleic acids (RNAs) are generally linear chains of nucleotides which function in many cellular processes, best known in protein biosynthesis. In the last decade, circular RNAs have been discovered which are circularized after their synthesis and differ in important features from linear RNAs. These circular RNAs have meanwhile been implicated in important cellular processes in health and disease. Here, we present a comprehensive database, circ2GO, compiling and analyzing circular RNAs found in lung cancer cell lines providing the data in tables as well as visualizing it in transcript maps and in heatmaps. Importantly, we also provide easy-to-use online tools to find circular forms of genes associated with specific molecular functions, biological processes or cellular components or predict their targeted microRNAs. This resource will enable researchers to rapidly identify circular RNAs relevant for their specific research question.