Geriatric Nutritional Risk Index Less Than 92 Is a Predictor for Late Postpancreatectomy Hemorrhage Following Pancreatoduodenectomy: A Retrospective Cohort Study
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. Patient Characteristics and Univariate Analysis for PPH risk Following PD
2.2. Receiver Operating Characteristic (ROC) Curve Analysis
2.3. Univariate Analysis of a GNRI < 92 for PPH
2.4. Multivariable with Logistic Regression Analyses
3. Discussion
4. Materials and Methods
4.1. Patients
4.2. Collection of Clinical and Laboratory Data
4.3. Definition of GNRI
4.4. Perioperative Management and Surgical Technique for PD
4.5. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Characteristics | PPH Group | Non-PPH Group | p-Value |
---|---|---|---|
(n = 10) | (n = 111) | ||
Gender | |||
Male vs Female | 10 vs. 0 | 69 vs. 42 | p = 0.01 |
Age (years) | 76.1 ± 2.0 | 70.8 ± 1.1 | p = 0.15 |
Body mass index | 22.7 ± 0.7 | 22.1 ± 0.3 | p = 0.55 |
ASA classification | |||
1 or 2 | 8 (80.0%) | 97 (87.4%) | p = 0.51 |
3 | 2 (20.0%) | 14 (12.6%) | |
Pancreatic or periampullary | 8 (80.0%) | 91 (82.0%) | p = 0.88 |
adenocarcinoma (%) | |||
Smoking habit (%) | 2 (20.0%) | 8 (7.2%) | p = 0.19 |
Alcohol intake (%) | 0 (0.0%) | 3 (2.7%) | p = 0.60 |
Diabetes mellitus (%) | 1 (10.0%) | 36 (32.4%) | p = 0.14 |
Neoadjuvant chemotherapy (%) | 0 (0.0%) | 9 (8.1%) | p = 0.35 |
Preoperative biliary drainage (%) | 6 (60.0%) | 35 (31.5%) | p = 0.09 |
Preoperative albumin (g/L) | 3.3 ± 0.1 | 3.9 ± 0.1 | p < 0.001 |
Robotic/open PD | 2/8 | 16/95 | p = 0.63 |
GNRI | 89.2 ± 1.9 | 98.3 ± 0.8 | p = 0.001 |
92< | 8 | 19 | p < 0.001 |
92≥ | 2 | 92 | |
Time taken for the operation (min) | 578.1 ± 42.2 | 497.2 ± 15.1 | p = 0.13 |
Estimated blood loss (ml) | 712.7 ± 103.5 | 656.2 ± 63.3 | p = 0.69 |
Blood transfusion (%) | 2 (20.0%) | 25 (22.5%) | p = 0.85 |
Portal vein resection (%) | 0 (0.0%) | 6 (5.4%) | p = 0.45 |
Bile leakage (%) | 2 (20.0%) | 5 (4.5%) | p = 0.09 |
Postoperative pancreatic fistula (%) | 7 (70.0%) | 27 (24.3%) | p = 0.005 |
Grade B or C (%) | |||
Rate of intraabdominal infection (%) | 6 (60.0%) | 24 (22.5%) | p = 0.02 |
Postoperative hospital stays (day) | 49.0 ± 8.2 | 22.9 ± 5.5 | p < 0.001 |
Variables | Odds Ratio | 95% Confidence Interval | p-Value |
---|---|---|---|
Gender | 0.001 | Not available | p = 0.97 |
Intra-abdominal abscess | 0.58 | 0.01–0.46 | p = 0.65 |
POPF | 4.11 | 0.44–38.29 | p = 0.21 |
GNRI < 92 | 0.07 | 0.01–0.46 | p = 0.006 |
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Funamizu, N.; Omura, K.; Takada, Y.; Ozaki, T.; Mishima, K.; Igarashi, K.; Wakabayashi, G. Geriatric Nutritional Risk Index Less Than 92 Is a Predictor for Late Postpancreatectomy Hemorrhage Following Pancreatoduodenectomy: A Retrospective Cohort Study. Cancers 2020, 12, 2779. https://doi.org/10.3390/cancers12102779
Funamizu N, Omura K, Takada Y, Ozaki T, Mishima K, Igarashi K, Wakabayashi G. Geriatric Nutritional Risk Index Less Than 92 Is a Predictor for Late Postpancreatectomy Hemorrhage Following Pancreatoduodenectomy: A Retrospective Cohort Study. Cancers. 2020; 12(10):2779. https://doi.org/10.3390/cancers12102779
Chicago/Turabian StyleFunamizu, Naotake, Kenji Omura, Yasutsugu Takada, Takahiro Ozaki, Kohei Mishima, Kazuharu Igarashi, and Go Wakabayashi. 2020. "Geriatric Nutritional Risk Index Less Than 92 Is a Predictor for Late Postpancreatectomy Hemorrhage Following Pancreatoduodenectomy: A Retrospective Cohort Study" Cancers 12, no. 10: 2779. https://doi.org/10.3390/cancers12102779