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Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer

1,2,3
1
Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Whitehead Research Bldg. Room 201, 615 Michael Street, Atlanta, GA 30322, USA
2
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
3
Atlanta VA Medical Center, Decatur, GA 30322, USA
Cancers 2019, 11(7), 958; https://doi.org/10.3390/cancers11070958
Received: 10 June 2019 / Revised: 4 July 2019 / Accepted: 8 July 2019 / Published: 9 July 2019
(This article belongs to the Special Issue Lysophosphatidic Acid Signalling in Cancer)
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PDF [440 KB, uploaded 9 July 2019]
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Abstract

The intestinal epithelium interacts dynamically with the immune system to maintain its barrier function to protect the host, while performing the physiological roles in absorption of nutrients, electrolytes, water and minerals. The importance of lysophosphatidic acid (LPA) and its receptors in the gut has been progressively appreciated. LPA signaling modulates cell proliferation, invasion, adhesion, angiogenesis, and survival that can promote cancer growth and metastasis. These effects are equally important for the maintenance of the epithelial barrier in the gut, which forms the first line of defense against the milieu of potentially pathogenic stimuli. This review focuses on the LPA-mediated signaling that potentially contributes to inflammation and tumor formation in the gastrointestinal tract. View Full-Text
Keywords: lysophosphatidic acid; colorectal cancer; inflammation; intestine lysophosphatidic acid; colorectal cancer; inflammation; intestine
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Yun, C.C. Lysophosphatidic Acid and Autotaxin-associated Effects on the Initiation and Progression of Colorectal Cancer. Cancers 2019, 11, 958.

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