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Open AccessReview

Salivary Extracellular Vesicle-Associated exRNA as Cancer Biomarker

Department of Medical Sciences, University of Torino, Torino 10126, Italy
2i3T Business Incubator and Technology Transfer, University of Torino, Torino 10126, Italy
Author to whom correspondence should be addressed.
Cancers 2019, 11(7), 891;
Received: 21 May 2019 / Revised: 11 June 2019 / Accepted: 22 June 2019 / Published: 26 June 2019
(This article belongs to the Special Issue Liquid Biopsy for Cancer)
PDF [801 KB, uploaded 1 July 2019]


Extracellular vesicles (EVs) secreted in biological fluids contain several transcripts of the cell of origin, which may modify the functions and phenotype of proximal and distant cells. Cancer-derived EVs may promote a favorable microenvironment for cancer growth and invasion by acting on stroma and endothelial cells and may favor metastasis formation. The transcripts contained in cancer EVs may be exploited as biomarkers. Protein and extracellular RNA (exRNA) profiling in patient bio-fluids, such as blood and urine, was performed to identify molecular features with potential diagnostic and prognostic values. EVs are concentrated in saliva, and salivary EVs are particularly enriched in exRNAs. Several studies were focused on salivary EVs for the detection of biomarkers either of non-oral or oral cancers. The present paper provides an overview of the available studies on the diagnostic potential of exRNA profiling in salivary EVs. View Full-Text
Keywords: miRNA; non coding RNA; exosomes; microvesicles; cancer; saliva miRNA; non coding RNA; exosomes; microvesicles; cancer; saliva

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chiabotto, G.; Gai, C.; Deregibus, M.C.; Camussi, G. Salivary Extracellular Vesicle-Associated exRNA as Cancer Biomarker. Cancers 2019, 11, 891.

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