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Morphology and Molecular Features of Rare Colorectal Carcinoma Histotypes

1
Pathology Unit, Services Department, ULSS9 “Scaligera”, 37122 Verona, Italy
2
Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, 35100 Padua, Italy
3
Unit of Anatomic Pathology, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
4
Department of Diagnostic, Clinic and Public Health Medicine, Anatomic Pathology, University of Modena and Reggio Emilia, 41121 Modena, Italy
5
Department of Diagnostic and Public Health, Section of Pathology, University of Verona, 37134 Verona, Italy
6
Department of Pathology, Istituto Nazionale Tumori Fondazione G. Pascale, IRCCS, 80131 Naples, Italy
7
Section of Anatomic Pathology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara and S. Anna University Hospital, 44121 Ferrara, Italy
8
U.O.C. Oncologia Medica, Ospedali Riuniti Azienda Ospedaliera Universitaria, 71122 Foggia, Italy
9
Department of Sciences and Technologies, University of Sannio, 82100 Benevento, Italy
10
Anatomic Pathology, Department of Integrated Surgical and Diagnostic Sciences (DISC), University of Genoa and Ospedale Policlinico San Martino, 16132 Genoa, Italy
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Cancers 2019, 11(7), 1036; https://doi.org/10.3390/cancers11071036
Received: 7 June 2019 / Revised: 15 July 2019 / Accepted: 18 July 2019 / Published: 23 July 2019
Several histopathological variants of colorectal carcinoma can be distinguished, some associated with specific molecular profiles. However, in routine practice, ninety/ninety-five percent of all large bowel tumors are diagnosed as conventional adenocarcinoma, even though they are a heterogeneous group including rare histotypes, which are often under-recognized. Indeed, colorectal cancer exhibits differences in incidence, location of tumor, pathogenesis, molecular pathways and outcome depending on histotype. The aim is therefore to review the morphological and molecular features of these rare variants of intestinal carcinomas which may hold the key to differences in prognosis and treatment. View Full-Text
Keywords: colorectal cancer histotypes; signet ring cell carcinoma; medullary carcinoma; lymphoepitelioma-like carcinoma; cribriform/comedo-type carcinoma; micropapillary carcinoma; clear cell carcinoma; hepatoid carcinoma; adenocarcinoma with osseous metaplasia; rhabdoid carcinoma colorectal cancer histotypes; signet ring cell carcinoma; medullary carcinoma; lymphoepitelioma-like carcinoma; cribriform/comedo-type carcinoma; micropapillary carcinoma; clear cell carcinoma; hepatoid carcinoma; adenocarcinoma with osseous metaplasia; rhabdoid carcinoma
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Remo, A.; Fassan, M.; Vanoli, A.; Bonetti, L.R.; Barresi, V.; Tatangelo, F.; Gafà, R.; Giordano, G.; Pancione, M.; Grillo, F.; Mastracci, L. Morphology and Molecular Features of Rare Colorectal Carcinoma Histotypes. Cancers 2019, 11, 1036.

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