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Uveal Melanoma: A European Network to Face the Many Challenges of a Rare Cancer

1
Department of Medical Oncology, Institut Curie, 75005 Paris, France
2
Department of Medical Oncology, Catalan Cancer Institute, IDIBELL, CIBERONC, Hospitalet de Llobregat, 08908 Barcelona, Spain
3
Department of Dermatology, University Hospital Würzburg, 97080 Würzburg, Germany
4
European Patient Advocacy Group: Melanoma Patient Network Europe & OcuMel, Birmingham B13 8ET, UK
5
Department of Melanoma, Maria Skłodowska Curie Institute-Oncology Centre, 02-034 Warsaw, Poland
6
Translational Skin Cancer Research, University of Essen-Duisburg, German Cancer Consortium (DKTK), 47057 Duisburg, Germany
7
Department of Oncology and FICAN West Cancer Center, Turku University Hospital, 20521 Turku, Finland
8
Department of Ophthalmology, UZ Leuven, 3000 Leuven, Belgium
9
Department of Ophthalmology, Università degli Studi di Siena UNISI, 53100 Siena, Italy
10
Onco-Ophthalmology National Reference Centre, CHUC, 3075 Coimbra, Portugal
11
Department of Ophthalmololgy, Bellvitge University Hospital, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
12
EURACAn coordination team, Centre Léon Bérard, 69008 Lyon, France
13
EURACAN network coordinator, Department of Medical Oncology, Centre Léon Bérard, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France
14
Department of Medical Oncology, LUMC, 2333 ZA Leiden, the Netherlands
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(6), 817; https://doi.org/10.3390/cancers11060817
Received: 20 May 2019 / Revised: 7 June 2019 / Accepted: 10 June 2019 / Published: 13 June 2019
(This article belongs to the Special Issue Uveal Melanoma)
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PDF [582 KB, uploaded 19 June 2019]
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Abstract

Uveal melanoma (UM) is the most frequent primary ocular cancer in adults, accounting for 5% of all melanomas. Despite effective treatments for the primary tumour, up to 50% of UM patients will develop metastasis, leading to a very poor prognosis and a median overall survival of 6 to 12 months, with no major improvements in the last 30 years. There is no standard oncological treatment available for metastatic UM patients, and BRAF/MEK and immune checkpoint inhibitors show disappointing results when compared to cutaneous melanoma (CM). Recent advances in biology, however, identified specific gene and chromosome alterations, potentially permitting an actively tailored surveillance strategy, and dedicated clinical studies. Being a rare cancer, UM patients have to overcome issues such as identifying referral centres, having access to information, and partnering with oncologists for specific management strategies and research priorities. Here, we describe how the European Rare Adult solid Cancer Network (EURACAN) will help in addressing these challenges and accelerating international collaborations to enhance the development of innovative treatments in UM. View Full-Text
Keywords: uveal melanoma; rare cancer; European Reference Network uveal melanoma; rare cancer; European Reference Network
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Piperno-Neumann, S.; Piulats, J.M.; Goebeler, M.; Galloway, I.; Lugowska, I.; Becker, J.C.; Vihinen, P.; Van Calster, J.; Hadjistilianou, T.; Proença, R.; Caminal, J.M.; Rogasik, M.; Blay, J.-Y.; Kapiteijn, E. Uveal Melanoma: A European Network to Face the Many Challenges of a Rare Cancer. Cancers 2019, 11, 817.

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