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Erratum: Cuceu, C., et al. Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability. Cancers 2018, 10, 233
Open AccessArticle

Semaphorin-7A on Exosomes: A Promigratory Signal in the Glioma Microenvironment

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Department of Medicine, University of Udine, Piazzale S. Maria della Misericordia 15, 33100 Udine, Italy
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Department of Life Sciences, University of Trieste, Via Giorgieri 5, 34127 Trieste, Italy
3
Department of Neurosurgery, University Hospital of Udine, Piazzale S. Maria della Misericordia 15, 33100 Udine, Italy
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(6), 758; https://doi.org/10.3390/cancers11060758
Received: 9 May 2019 / Revised: 24 May 2019 / Accepted: 25 May 2019 / Published: 30 May 2019
(This article belongs to the Special Issue Tumors of the Central Nervous System: An Update)
Exosomes are one of the most important mediators of the cross talk occurring between glioma stem cells (GSCs) and the surrounding microenvironment. We have previously shown that exosomes released by patient-derived glioma-associated stem cells (GASC) are able to increase, in vitro, the aggressiveness of both GSC and glioblastoma cell lines. To understand which molecules are responsible for this tumour-supporting function, we performed a descriptive proteomic analysis of GASC-exosomes and identified, among the others, Semaphorin7A (SEMA7A). SEMA7A was described as a promigratory cue in physiological and pathological conditions, and we hypothesised that it could modulate GSC migratory properties. Here, we described that SEMA7A is exposed on GASC-exosomes’ surface and signals to GSC through Integrin β1. This interaction activates focal adhesion kinase into GSC and increases their motility, in our patient-based in vitro model. Our findings suggest SEMA7A-β1-integrin as a new target to disrupt the communication between GSCs and the supporting microenvironment. View Full-Text
Keywords: glioblastoma microenvironment; exosomes; Semaphorin 7A; integrin β1/FAK signalling; motility glioblastoma microenvironment; exosomes; Semaphorin 7A; integrin β1/FAK signalling; motility
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Manini, I.; Ruaro, M.E.; Sgarra, R.; Bartolini, A.; Caponnetto, F.; Ius, T.; Skrap, M.; Di Loreto, C.; Beltrami, A.P.; Manfioletti, G.; Cesselli, D. Semaphorin-7A on Exosomes: A Promigratory Signal in the Glioma Microenvironment. Cancers 2019, 11, 758.

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