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Cancers 2019, 11(4), 552; https://doi.org/10.3390/cancers11040552

Clinical Implications of Noncoding Indels in the Surfactant-Encoding Genes in Lung Cancer

1
Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, Yamanashi 400-8506, Japan
2
Department of Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan
3
Genome Analysis Center, Yamanashi Central Hospital, Yamanashi 400-8506, Japan
4
Department of Pathology, Yamanashi Central Hospital, Yamanashi 400-8506, Japan
5
Department of Gastroenterology, The University of Tokyo Hospital, Tokyo 113-8655, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 19 March 2019 / Revised: 12 April 2019 / Accepted: 13 April 2019 / Published: 17 April 2019
PDF [1581 KB, uploaded 18 April 2019]
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Abstract

Lung cancer arises from the accumulation of genetic mutations, usually in exons. A recent study identified indel mutations in the noncoding region of surfactant-encoding genes in lung adenocarcinoma cases. In this study, we recruited 94 patients with 113 lung cancers (88 adenocarcinomas, 16 squamous cell carcinomas, and nine other histologies) who had undergone surgery in our department. A cancer panel was designed in-house for analyzing the noncoding regions, and targeted sequencing was performed. Indels in the noncoding region of surfactant-encoding genes were identified in 29/113 (25.7%) cases and represent the precise cell of origin for the lung cancer, irrespective of histological type and/or disease stage. In clinical practice, these indels may be used as clonal markers in patients with multiple cancers and to determine the origin of cancer of unknown primary site.
Keywords: indel; untranslated region; lung cancer; mutation; targeted sequencing; cancer of unknown origin indel; untranslated region; lung cancer; mutation; targeted sequencing; cancer of unknown origin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nakagomi, T.; Hirotsu, Y.; Goto, T.; Shikata, D.; Yokoyama, Y.; Higuchi, R.; Otake, S.; Amemiya, K.; Oyama, T.; Mochizuki, H.; Omata, M. Clinical Implications of Noncoding Indels in the Surfactant-Encoding Genes in Lung Cancer. Cancers 2019, 11, 552.

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