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Gastric Cancer in Northern Canadian Populations: A Focus on Cardia and Non-Cardia Subsites

1
School of Public Health, University of Alberta, Edmonton, AB T6G 1C9, Canada
2
Department of Health and Social Services, Government of the Northwest Territories, Yellowknife, NT X1A 2L9, Canada
3
Department of Health and Social Services, Government of Yukon, Whitehorse, YT Y1A 1Z4, Canada
4
Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada
5
The CANHelp Working Group, University of Alberta, Edmonton, AB T6G 2E1, Canada
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(4), 534; https://doi.org/10.3390/cancers11040534
Received: 28 February 2019 / Revised: 29 March 2019 / Accepted: 4 April 2019 / Published: 15 April 2019
(This article belongs to the Special Issue Helicobacter pylori Associated Cancer)
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Abstract

In northern Canada where there is a high prevalence of Helicobacter pylori infection, there is a paucity of information on gastric cancer by the topographical subsites cardia (CGC) and non-cardia (NCGC). Here we describe the incidence of CGC and NCGC, separately, among northern Canadian populations. We used data from the Cancer Incidence in Five Continents Volumes X (CI5X) and XI (CI5XI) to obtain CGC and NCGC incidence for Canada and for Yukon (YT), a northern Canadian territory. Using these data with those provided by the Government of the Northwest Territories (NT), we estimated standardized incidence ratios comparing northern populations to Canada as a whole. We also estimated age-standardized incidence rates to permit comparisons across populations globally. NT and YT populations were disproportionately impacted by gastric cancer, particularly NCGC. This was especially true for Indigenous populations: NCGC incidence rates among NT Indigenous men were 2.7 times the rates among all men in Canada, while rates among NT Indigenous women were 3.1 times the rates among all women in Canada. Similarly, age-standardized rates of NCGC among Indigenous NT residents were comparable to global regions where there is a high burden of NCGC. This study has, for the first time, quantified the incidence of CGC and NCGC for the NT and YT, providing new insights into the burden of these cancers among northern Canadian populations. View Full-Text
Keywords: gastric cancer; cardia; incidence; epidemiology; Arctic; Canada; Indigenous health; Helicobacter pylori gastric cancer; cardia; incidence; epidemiology; Arctic; Canada; Indigenous health; Helicobacter pylori
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Colquhoun, A.; Hannah, H.; Corriveau, A.; Hanley, B.; Yuan, Y.; Goodman, K.J.; The CANHelp Working Group. Gastric Cancer in Northern Canadian Populations: A Focus on Cardia and Non-Cardia Subsites. Cancers 2019, 11, 534.

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