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Use of Dendritic Cell Receptors as Targets for Enhancing Anti-Cancer Immune Responses

Department of Medicinal and Biological Chemistry, University of Toledo, Toledo, 43614 OH, USA
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Author to whom correspondence should be addressed.
Cancers 2019, 11(3), 418; https://doi.org/10.3390/cancers11030418
Received: 27 February 2019 / Accepted: 19 March 2019 / Published: 24 March 2019
(This article belongs to the Special Issue Tumour Associated Dendritic Cells)
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Abstract

A successful anti-cancer vaccine construct depends on its ability to induce humoral and cellular immunity against a specific antigen. Targeting receptors of dendritic cells to promote the loading of cancer antigen through an antibody-mediated antigen uptake mechanism is a promising strategy in cancer immunotherapy. Researchers have been targeting different dendritic cell receptors such as Fc receptors (FcR), various C-type lectin-like receptors such as dendritic and thymic epithelial cell-205 (DEC-205), dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), and Dectin-1 to enhance the uptake process and subsequent presentation of antigen to T cells through major histocompatibility complex (MHC) molecules. In this review, we compare different subtypes of dendritic cells, current knowledge on some important receptors of dendritic cells, and recent articles on targeting those receptors for anti-cancer immune responses in mouse models. View Full-Text
Keywords: dendritic cells; Fc receptor; C-type lectin receptor; major histocompatibility complex (MHC); immunotherapy dendritic cells; Fc receptor; C-type lectin receptor; major histocompatibility complex (MHC); immunotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hossain, M.K.; Wall, K.A. Use of Dendritic Cell Receptors as Targets for Enhancing Anti-Cancer Immune Responses. Cancers 2019, 11, 418.

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