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Cancers 2019, 11(2), 246; https://doi.org/10.3390/cancers11020246

FBXW7 in Cancer: What Has Been Unraveled Thus Far?

1
Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India
2
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117 600, Singapore
3
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117 600, Singapore
4
Medical Science Cluster, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117 600, Singapore
5
Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA 6845, Australia
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The School of Stomatology, Fujian Medical University, 1 Xue Yuan Road, University Town, Fuzhou 350108, Fujian, China
7
Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun District, Guangzhou 510405, Guangdong, China
8
Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, China
*
Authors to whom correspondence should be addressed.
Received: 18 January 2019 / Revised: 7 February 2019 / Accepted: 11 February 2019 / Published: 19 February 2019
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PDF [1348 KB, uploaded 26 February 2019]
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Abstract

The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system (UPS) thus regulating cellular growth. FBXW7 is considered as a potent tumor suppressor as most of its target substrates can function as potential growth promoters, including c-Myc, Notch, cyclin E, c-JUN, and KLF5. Its regulators include p53, C/EBP-δ, Numb, microRNAs, Pin 1, Hes-5, BMI1, Ebp2. Mounting evidence has indicated the involvement of aberrant expression of FBXW7 for tumorigenesis. Moreover, numerous studies have also shown its role in cancer cell chemosensitization, thereby demonstrating the importance of FBXW7 in the development of curative cancer therapy. This comprehensive review emphasizes on the targets, functions, regulators and expression of FBXW7 in different cancers and its involvement in sensitizing cancer cells to chemotherapeutic drugs. View Full-Text
Keywords: FBXW7; SCF complex; tumor suppressor; mutations; cancer; chemoresistance; chemosensitization FBXW7; SCF complex; tumor suppressor; mutations; cancer; chemoresistance; chemosensitization
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Sailo, B.L.; Banik, K.; Girisa, S.; Bordoloi, D.; Fan, L.; Halim, C.E.; Wang, H.; Kumar, A.P.; Zheng, D.; Mao, X.; Sethi, G.; Kunnumakkara, A.B. FBXW7 in Cancer: What Has Been Unraveled Thus Far? Cancers 2019, 11, 246.

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