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Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets

Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
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Cancers 2019, 11(12), 1972; https://doi.org/10.3390/cancers11121972
Received: 31 October 2019 / Revised: 4 December 2019 / Accepted: 5 December 2019 / Published: 7 December 2019
Protein kinases are critical regulators of signaling cascades that control cellular proliferation, growth, survival, metabolism, migration, and invasion. Deregulation of kinase activity can lead to aberrant regulation of biological processes and to the onset of diseases, including cancer. In this review, we focus on oncogenic kinases and the signaling pathways they regulate that underpin tumor development. We highlight genomic biomarker-based precision medicine intervention strategies that match kinase inhibitors alone or in combination to mutationally activated kinase drivers, as well as progress towards implementation of these treatment strategies in the clinic. We also discuss the challenges for identification of novel protein kinase cancer drivers in the genomic era. View Full-Text
Keywords: oncogenes; kinases; precision therapies; therapy resistance; signal transduction; driver mutation oncogenes; kinases; precision therapies; therapy resistance; signal transduction; driver mutation
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Torres-Ayuso, P.; Brognard, J. Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets. Cancers 2019, 11, 1972.

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