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Review

Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer

1
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China
2
Department of Anatomical and cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2018, 10(7), 210; https://doi.org/10.3390/cancers10070210
Received: 17 May 2018 / Revised: 9 June 2018 / Accepted: 13 June 2018 / Published: 21 June 2018
(This article belongs to the Special Issue Epstein–Barr Virus Associated Cancers)
Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct types of aggressive head and neck cancers with early age onsets. Their recently identified genomic landscapes by whole-exome sequencing (WES) clearly reveal critical roles of: (1) inflammation via NF-kB activation, (2) survival via PI3K aberrations, and perhaps (3) immune evasion via MHC loss in these cancers as summarized in this review. Immediate outcomes of these WES studies include the identification of potential prognostic biomarkers, and druggable events for these cancers. The impact of these genomic findings on the development of precision medicine and immunotherapies will be discussed. For both of these cancers, the main lethality comes from metastases and disease recurrences which may represent therapy resistance. Thus, potential curing of these cancers still relies on future identification of key genomic drivers and likely druggable events in recurrent and metastatic forms of these intrinsically aggressive cancers of the head and neck. View Full-Text
Keywords: EBV(+) NPC; HPV(+) HNSCC; genomic profiles EBV(+) NPC; HPV(+) HNSCC; genomic profiles
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MDPI and ACS Style

Ngan, H.-L.; Wang, L.; Lo, K.-W.; Lui, V.W.Y. Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer. Cancers 2018, 10, 210. https://doi.org/10.3390/cancers10070210

AMA Style

Ngan H-L, Wang L, Lo K-W, Lui VWY. Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer. Cancers. 2018; 10(7):210. https://doi.org/10.3390/cancers10070210

Chicago/Turabian Style

Ngan, Hoi-Lam, Lan Wang, Kwok-Wai Lo, and Vivian Wai Yan Lui. 2018. "Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer" Cancers 10, no. 7: 210. https://doi.org/10.3390/cancers10070210

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