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Micromachines 2018, 9(6), 300; https://doi.org/10.3390/mi9060300

Liquid Biopsy in Colorectal Cancer-Current Status and Potential Clinical Applications

Department of Abdominal Surgery, University Medical Centre Ljubljana, Zaloska Cesta 7, Ljubljana 1000, Slovenia
Received: 27 April 2018 / Revised: 7 June 2018 / Accepted: 12 June 2018 / Published: 15 June 2018
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Abstract

Colorectal cancer is one of the most frequent solid malignancies worldwide. The treatment is either surgical or multimodal and depends on the stage of the disease at diagnosis. Accurate disease assessment is thus of great importance for choosing the most optimal treatment strategy. However, the standard means of disease assessment by radiological imaging or histopathological analysis of the removed tumor tissue lack the sensitivity in detecting the early systemic spread of the disease. To overcome this deficiency, the concept of liquid biopsy from the peripheral blood of patients has emerged as a new, very promising diagnostic tool. In this article, we provide an overview of the current status of clinical research on liquid biopsy in colorectal cancer. We also highlight the clinical situations in which the concept might be of the greatest benefit for the management of colorectal cancer patients in the future. View Full-Text
Keywords: colorectal cancer; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); liquid biopsy; lab-on-a-chip colorectal cancer; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); liquid biopsy; lab-on-a-chip
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Norcic, G. Liquid Biopsy in Colorectal Cancer-Current Status and Potential Clinical Applications. Micromachines 2018, 9, 300.

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