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Numerical Investigation of a Novel Wiring Scheme Enabling Simple and Accurate Impedance Cytometry

Department of Civil Engineering and Computer Science, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Rome, Italy
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Micromachines 2017, 8(9), 283; https://doi.org/10.3390/mi8090283
Received: 13 August 2017 / Revised: 6 September 2017 / Accepted: 12 September 2017 / Published: 18 September 2017
(This article belongs to the Special Issue Microfluidic Devices for High-Throughput Screening)
Microfluidic impedance cytometry is a label-free approach for high-throughput analysis of particles and cells. It is based on the characterization of the dielectric properties of single particles as they flow through a microchannel with integrated electrodes. However, the measured signal depends not only on the intrinsic particle properties, but also on the particle trajectory through the measuring region, thus challenging the resolution and accuracy of the technique. In this work we show via simulation that this issue can be overcome without resorting to particle focusing, by means of a straightforward modification of the wiring scheme for the most typical and widely used microfluidic impedance chip. View Full-Text
Keywords: microfluidics; electrical impedance; single-cell analysis; lab-on-a-chip; finite element method; virtual laboratory microfluidics; electrical impedance; single-cell analysis; lab-on-a-chip; finite element method; virtual laboratory
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Caselli, F.; Reale, R.; Nodargi, N.A.; Bisegna, P. Numerical Investigation of a Novel Wiring Scheme Enabling Simple and Accurate Impedance Cytometry. Micromachines 2017, 8, 283.

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