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Open AccessArticle

An Integrated Artificial Cilia Based Microfluidic Device for Micropumping and Micromixing Applications

by Yu-An Wu 1,†, Bivas Panigrahi 1,†, Yueh-Hsun Lu 2,3 and Chia-Yuan Chen 1,*
Department of Mechanical Engineering, National Cheng Kung University, Tainan 701, Taiwan
Department of Radiology, Taipei City Hospital, Zhongxing branch, Taipei 103, Taiwan
Department of Radiology, National Yang-Ming University, Taipei 112, Taiwan
Author to whom correspondence should be addressed.
All the authors have contributed equally towards this work.
Micromachines 2017, 8(9), 260;
Received: 25 March 2017 / Revised: 9 August 2017 / Accepted: 17 August 2017 / Published: 24 August 2017
(This article belongs to the Special Issue Lab-on-a-Chip)
A multi-purpose microfluidic device that can be used for both micromixing and micropropulsion operations has always been in demand, as it would simplify the various process flows associated with the current micro-total analysis systems. In this aspect, we propose a biomimetic artificial cilia-based microfluidic device that can efficiently facilitate both mixing and propulsion sequentially at the micro-scale. A rectangular microfluidic device consists of four straight microchannels that were fabricated using the microfabrication technique. An array of artificial cilia was embedded within one of the channel’s confinement through the aforementioned technique. A series of image processing and micro-particle image velocimetry technologies were employed to elucidate the micromixing and micropropulsion phenomena. Experiment results demonstrate that, with this proposed microfluidic device, a maximum micromixing efficiency and flow rate of 0.84 and 0.089 µL/min, respectively, can be achieved. In addition to its primary application as a targeted drug delivery system, where a drug needs to be homogeneously mixed with its carrier prior to its administration into the target body, this microfluidic device can be used as a micro-total analysis system for the handling of other biological specimens. View Full-Text
Keywords: artificial cilia; micromixing; micropropulsion; micro-particle image velocimetry (µPIV); hydrodynamics artificial cilia; micromixing; micropropulsion; micro-particle image velocimetry (µPIV); hydrodynamics
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MDPI and ACS Style

Wu, Y.-A.; Panigrahi, B.; Lu, Y.-H.; Chen, C.-Y. An Integrated Artificial Cilia Based Microfluidic Device for Micropumping and Micromixing Applications. Micromachines 2017, 8, 260.

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