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Micromachines 2017, 8(4), 130;

A Micromanipulator and Transporter Based on Vibrating Bubbles in an Open Chip Environment

State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 10016, China
University of Chinese Academy of Sciences, Beijing 100049, China
Authors to whom correspondence should be addressed.
Academic Editors: Aaron T. Ohta, Wenqi Hu and Nam-Trung Nguyen
Received: 13 January 2017 / Revised: 22 March 2017 / Accepted: 7 April 2017 / Published: 18 April 2017
(This article belongs to the Special Issue Microdevices and Microsystems for Cell Manipulation)
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A novel micromanipulation technique of multi-objectives based on vibrating bubbles in an open chip environment is described in this paper. Bubbles were created in an aqueous medium by the thermal energy converted from a laser. When the piezoelectric stack fixed under the chip vibrated the bubbles, micro-objects (microparticles, cells, etc.) rapidly moved towards the bubbles. Results from numerical simulation demonstrate that convective flow around the bubbles can provide forces to capture objects. Since bubbles can be generated at arbitrary destinations in the open chip environment, they can act as both micromanipulators and transporters. As a result, micro- and bio-objects could be collected and transported effectively as masses in the open chip environment. This makes it possible for scientific instruments, such as atomic force microscopy (AFM) and scanning ion conductive microscopy (SICM), to operate the micro-objects directly in an open chip environment. View Full-Text
Keywords: vibrating bubble; micromanipulation; cell trapping; open chip environment vibrating bubble; micromanipulation; cell trapping; open chip environment

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Dai, L.; Jiao, N.; Wang, X.; Liu, L. A Micromanipulator and Transporter Based on Vibrating Bubbles in an Open Chip Environment. Micromachines 2017, 8, 130.

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