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Open AccessArticle

Gravity-Based Precise Cell Manipulation System Enhanced by In-Phase Mechanism

Department of Mechanical Engineering, Osaka University, Suita 565-0871, Japan
Department of Mechanical Engineering, Pohang 790-784, Korea
Author to whom correspondence should be addressed.
Academic Editor: Abel Martin Gonzalez Oliva
Micromachines 2016, 7(7), 116;
Received: 19 May 2016 / Revised: 30 June 2016 / Accepted: 5 July 2016 / Published: 9 July 2016
(This article belongs to the Special Issue Advances in Microfluidic Devices for Cell Handling and Analysis)
This paper proposes a gravity-based system capable of generating high-resolution pressure for precise cell manipulation or evaluation in a microfluidic channel. While the pressure resolution of conventional pumps for microfluidic applications is usually about hundreds of pascals as the resolution of their feedback sensors, precise cell manipulation at the pascal level cannot be done. The proposed system successfully achieves a resolution of 100 millipascals using water head pressure with an in-phase noise cancelation mechanism. The in-phase mechanism aims to suppress the noises from ambient vibrations to the system. The proposed pressure system is tested with a microfluidic platform for pressure validation. The experimental results show that the in-phase mechanism effectively reduces the pressure turbulence, and the pressure-driven cell movement matches the theoretical simulations. Preliminary experiments on deformability evaluation with red blood cells under incremental pressures of one pascal are successfully performed. Different deformation patterns are observed from cell to cell under precise pressure control. View Full-Text
Keywords: cell manipulation; pressure control; microfluidics; cell deformability cell manipulation; pressure control; microfluidics; cell deformability
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MDPI and ACS Style

Mizoue, K.; Phan, M.H.; Tsai, C.-H.D.; Kaneko, M.; Kang, J.; Chung, W.K. Gravity-Based Precise Cell Manipulation System Enhanced by In-Phase Mechanism. Micromachines 2016, 7, 116.

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