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Open AccessCommunication
Micromachines 2016, 7(7), 113;

Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment

Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Japan Science and Technology Agency (JST), PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Sapporo 060-8628, Japan
Department of Ophthalmology, School of Medicine, Keio University, Tokyo 160-8582, Japan
Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu 761-0395, Japan
Authors to whom correspondence should be addressed.
Academic Editors: Andrew J. deMello and Nam-Trung Nguyen
Received: 27 May 2016 / Revised: 22 June 2016 / Accepted: 30 June 2016 / Published: 4 July 2016
(This article belongs to the Special Issue Micro/Nano Devices for Chemical Analysis)
Full-Text   |   PDF [2214 KB, uploaded 4 July 2016]   |  


Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops. View Full-Text
Keywords: dry eye; autologous serum eye-drops; spiral microchannel dry eye; autologous serum eye-drops; spiral microchannel

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Yasui, T.; Morikawa, J.; Kaji, N.; Tokeshi, M.; Tsubota, K.; Baba, Y. Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment. Micromachines 2016, 7, 113.

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