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Open AccessArticle

Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices

1
Department of Electronic Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
2
Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Heinrich-Mußmann-Str. 1, Jülich 52428, Germany
3
Peter-Grünberg Institute (PGI-8), Research Centre Jülich, Jülich 52425, Germany
4
Department of Biomedical Engineering, Tohoku University, 6-6-05 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Manabu Tokeshi and Kiichi Sato
Micromachines 2016, 7(7), 111; https://doi.org/10.3390/mi7070111
Received: 18 May 2016 / Revised: 17 June 2016 / Accepted: 28 June 2016 / Published: 1 July 2016
(This article belongs to the Special Issue Micro/Nano Devices for Chemical Analysis)
A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement. View Full-Text
Keywords: chemical sensor; plug-based microfluidic device; light-addressable potentiometric sensor chemical sensor; plug-based microfluidic device; light-addressable potentiometric sensor
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MDPI and ACS Style

Miyamoto, K.-I.; Sato, T.; Abe, M.; Wagner, T.; Schöning, M.J.; Yoshinobu, T. Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices. Micromachines 2016, 7, 111.

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