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Micromachines 2016, 7(1), 11;

Temperature Sensing in Modular Microfluidic Architectures

Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, USA
Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
Author to whom correspondence should be addressed.
Academic Editor: Jeong-Bong Lee
Received: 8 December 2015 / Revised: 28 December 2015 / Accepted: 6 January 2016 / Published: 18 January 2016
(This article belongs to the Collection Lab-on-a-Chip)
PDF [4966 KB, uploaded 18 January 2016]


A discrete microfluidic element with integrated thermal sensor was fabricated and demonstrated as an effective probe for process monitoring and prototyping. Elements were constructed using stereolithography and market-available glass-bodied thermistors within the modular, standardized framework of previous discrete microfluidic elements demonstrated in the literature. Flow rate-dependent response due to sensor self-heating and microchannel heating and cooling was characterized and shown to be linear in typical laboratory conditions. An acid-base neutralization reaction was performed in a continuous flow setting to demonstrate applicability in process management: the ratio of solution flow rates was varied to locate the equivalence point in a titration, closely matching expected results. This element potentially enables complex, three-dimensional microfluidic architectures with real-time temperature feedback and flow rate sensing, without application specificity or restriction to planar channel routing formats. View Full-Text
Keywords: modular microfluidics; thermal sensor; flow sensor modular microfluidics; thermal sensor; flow sensor

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bhargava, K.C.; Thompson, B.; Tembhekar, A.; Malmstadt, N. Temperature Sensing in Modular Microfluidic Architectures. Micromachines 2016, 7, 11.

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