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Micromachines 2015, 6(11), 1794-1804;

Constriction Channel Based Single-Cell Mechanical Property Characterization

State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China
Department of Cellular and Molecular Biology, Beijing Chest Hospital, Capital Medical University, Beijing101149, China
This paper is an extended version of our paper published in the 5th International Conference on Optofluidics 2015, Taipei, Taiwan, 26–29 July 2015.
Authors to whom correspondence should be addressed.
Academic Editors: Shih-Kang Fan, Da-Jeng Yao and Yi-Chung Tung
Received: 2 September 2015 / Revised: 2 November 2015 / Accepted: 10 November 2015 / Published: 16 November 2015
(This article belongs to the Special Issue Optofluidics 2015)
Full-Text   |   PDF [3110 KB, uploaded 16 November 2015]   |  


This mini-review presents recent progresses in the development of microfluidic constriction channels enabling high-throughput mechanical property characterization of single cells. We first summarized the applications of the constriction channel design in quantifying mechanical properties of various types of cells including red blood cells, white blood cells, and tumor cells. Then we highlighted the efforts in modeling the cellular entry process into the constriction channel, enabling the translation of raw mechanical data (e.g., cellular entry time into the constriction channel) into intrinsic cellular mechanical properties such as cortical tension or Young’s modulus. In the end, current limitations and future research opportunities of the microfluidic constriction channels were discussed. View Full-Text
Keywords: single-cell analysis; microfluidics; constriction channel; mechanical property characterization; high throughput single-cell analysis; microfluidics; constriction channel; mechanical property characterization; high throughput

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Xue, C.; Wang, J.; Zhao, Y.; Chen, D.; Yue, W.; Chen, J. Constriction Channel Based Single-Cell Mechanical Property Characterization. Micromachines 2015, 6, 1794-1804.

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