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Micromachines 2014, 5(4), 1002-1011;

Generation of Nanoliter Droplets on Demand at Hundred-Hz Frequencies

Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland
Author to whom correspondence should be addressed.
Received: 25 August 2014 / Revised: 30 October 2014 / Accepted: 30 October 2014 / Published: 4 November 2014
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We describe a precision micropump for generation of precisely metered micro-aliquots of liquid at high rates. The use of custom designed piezoelectric valves positioned externally to the microfluidic chip allows for on-demand formation of micro-droplets with online control of their individual volumes from nLs to μLs at frequencies up to 400 Hz. The system offers precision of administering volumes of 1% and of time of emission of <0.5 ms. The use of a piezoelectric actuator provides two distinct vistas for controlling the volume of the droplets—either by digital control of the “open” interval or by analogue tuning of the lumen of the valve. Fast and precise generation of droplets make this system a perfect constituent module for microfluidic high-speed combinatorial screening schemes. View Full-Text
Keywords: microfluidics; droplets on demand; nanoliter droplets; piezoelectric valve microfluidics; droplets on demand; nanoliter droplets; piezoelectric valve

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Jakiela, S.; Debski, P.R.; Dabrowski, B.; Garstecki, P. Generation of Nanoliter Droplets on Demand at Hundred-Hz Frequencies. Micromachines 2014, 5, 1002-1011.

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