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Open AccessArticle

Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array

1
Laboratory for MEMS Applications, Department of Microsystems Engineering, IMTEK, University of Freiburg, Georges-Koehler-Allee 103, 79110 Freiburg, Germany
2
HSG-IMIT, Institut für Mikro- und Informationstechnik, Georges-Koehler-Allee 103, 79110 Freiburg, Germany
3
BIOSS—Centre for Biological Signalling Studies, University Freiburg, 79104 Freiburg, Germany
4
BIOS-Lab on chip group, MESA+ Institution of Nanotechnology, University of Twente, 7522 NH Enschede, The Netherlands
*
Author to whom correspondence should be addressed.
Micromachines 2013, 4(1), 80-89; https://doi.org/10.3390/mi4010080
Received: 17 December 2012 / Revised: 11 February 2013 / Accepted: 1 March 2013 / Published: 14 March 2013
We present a continuous-flow active micromixer based on channel-wall deflection in a polydimethylsiloxane (PDMS) chip for volume flows in the range up to 2 μL s−1 which is intended as a novel unit operation for the microfluidic Braille pin actuated platform. The chip design comprises a main microchannel connected to a series of side channels with dead ends aligned on the Braille pins. Computer-controlled deflection of the side-channel walls induces chaotic advection in the main-channel, which substantially accelerates mixing in low-Reynolds number flow. Sufficient mixing (mixing index MI below 0.1) of volume flows up to 0.5 μL s−1 could be achieved within residence times ~500 ms in the micromixer. As an application, continuous dilution of a yeast cell sample by a ratio down to 1:10 was successfully demonstrated. The mixer is intended to serve as a component of bio-analytical devices or as a unit operation in the microfluidic Braille pin actuated platform. View Full-Text
Keywords: active micromixer; continuous-flow; chaotic advection; channel wall deflection; PDMS chip; cell sample dilution; microfluidic Braille pin actuated platform active micromixer; continuous-flow; chaotic advection; channel wall deflection; PDMS chip; cell sample dilution; microfluidic Braille pin actuated platform
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MDPI and ACS Style

Abbas, Y.; Miwa, J.; Zengerle, R.; Von Stetten, F. Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array. Micromachines 2013, 4, 80-89.

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