A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications

Gharbi, Amina; Kallel, Ahmed Yahia; Kanoun, Olfa; Cheikhrouhou-Koubaa, Wissem; Contag, Christopher H.; Antoniac, Iulian; Derbel, Nabil; Ashammakhi, Nureddin

doi:10.3390/mi14010226

Open AccessArticle

A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications

by

Amina Gharbi

^1,2,*,

Ahmed Yahia Kallel

³

,

Olfa Kanoun

³

,

Wissem Cheikhrouhou-Koubaa

²

,

Christopher H. Contag

⁴,

Iulian Antoniac

⁵

,

Nabil Derbel

¹ and

Nureddin Ashammakhi

^4,*

¹

CEM Lab, National Engineering School of Sfax, Sfax University, Sfax 3018, Tunisia

²

Technopole de Sfax. BP 275, LT2S Lab, Centre de Recherche en Numérique de Sfax, Sfax 3000, Tunisia

³

MST, Chair for Measurement and Sensor Technology, Technische Universittät Chemnitz, 09111 Chemnitz, Germany

⁴

Institute for Quantitative Health Science and Engineering (IQ) and Department of Biomedical Engineering (BME), Michigan State University, East Lansing, MI 48824, USA

⁵

SIM, Faculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Bucharest, Romania

^*

Authors to whom correspondence should be addressed.

Micromachines 2023, 14(1), 226; https://doi.org/10.3390/mi14010226

Submission received: 17 November 2022 / Revised: 7 January 2023 / Accepted: 8 January 2023 / Published: 15 January 2023

(This article belongs to the Special Issue Feature Papers of Micromachines in Biology and Biomedicine 2022)

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Abstract

Monitoring changes in edema-associated intracranial pressure that complicates trauma or surgery would lead to improved outcomes. Implantable pressure sensors have been explored, but these sensors require post-surgical removal, leading to the risk of injury to brain tissue. The use of biodegradable implantable sensors would help to eliminate this risk. Here, we demonstrate a bioactive glass (BaG)-based hydration sensor. Fluorine (CaF₂) containing BaG (BaG-F) was produced by adding 5, 10 or 20 wt.% of CaF₂ to a BaG matrix using a melting manufacturing technique. The structure, morphology and electrical properties of the resulting constructs were evaluated to understand the physical and electrical behaviors of this BaG-based sensor. Synthesis process for the production of the BaG-F-based sensor was validated by assessing the structural and electrical properties. The structure was observed to be amorphous and dense, the porosity decreased and grain size increased with increasing CaF₂ content in the BaG matrix. We demonstrated that this BaG-F chemical composition is highly sensitive to hydration, and that the electrical sensitivity (resistive–capacitive) is induced by hydration and reversed by dehydration. These properties make BaG-F suitable for use as a humidity sensor to monitor brain edema and, consequently, provide an alert for increased intracranial pressure.

Keywords: bioactive glass; biodegradable; brain edema; capacitive sensor; hydration monitoring

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MDPI and ACS Style

Gharbi, A.; Kallel, A.Y.; Kanoun, O.; Cheikhrouhou-Koubaa, W.; Contag, C.H.; Antoniac, I.; Derbel, N.; Ashammakhi, N. A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications. Micromachines 2023, 14, 226. https://doi.org/10.3390/mi14010226

AMA Style

Gharbi A, Kallel AY, Kanoun O, Cheikhrouhou-Koubaa W, Contag CH, Antoniac I, Derbel N, Ashammakhi N. A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications. Micromachines. 2023; 14(1):226. https://doi.org/10.3390/mi14010226

Chicago/Turabian Style

Gharbi, Amina, Ahmed Yahia Kallel, Olfa Kanoun, Wissem Cheikhrouhou-Koubaa, Christopher H. Contag, Iulian Antoniac, Nabil Derbel, and Nureddin Ashammakhi. 2023. "A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications" Micromachines 14, no. 1: 226. https://doi.org/10.3390/mi14010226

APA Style

Gharbi, A., Kallel, A. Y., Kanoun, O., Cheikhrouhou-Koubaa, W., Contag, C. H., Antoniac, I., Derbel, N., & Ashammakhi, N. (2023). A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications. Micromachines, 14(1), 226. https://doi.org/10.3390/mi14010226

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A Biodegradable Bioactive Glass-Based Hydration Sensor for Biomedical Applications

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