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Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review

1
State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, Dalian 116023, China
2
College of Pharmaceutical Science, Soochow University, Suzhou 215123, China
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Health Science Center, Shenzhen University, Shenzhen 518060, China
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Biotechnologhy Division, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
5
College of Stomatology, Dalian Medical University, Dalian 116011, China
*
Authors to whom correspondence should be addressed.
Micromachines 2020, 11(4), 381; https://doi.org/10.3390/mi11040381
Received: 1 March 2020 / Revised: 20 March 2020 / Accepted: 25 March 2020 / Published: 3 April 2020
(This article belongs to the Special Issue Lab-on-a-Chip Systems for Toxicology)
Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in a single device, which facilitates evaluation of toxicity of drug metabolites. Human organ-on-a-chip has been fabricated and used to assess drug toxicity with data correlation with the clinical trial. In this review, we introduced the microfluidic chip models of liver, kidney, heart, nerve, and other organs and multiple organs, highlighting the application of these models in drug toxicity detection. Some biomarkers of toxic injury that have been used in organ chip platforms or have potential for use on organ chip platforms are summarized. Finally, we discussed the goals and future directions for drug toxicity evaluation based on organ-on-a-chip technology. View Full-Text
Keywords: organ-on-a-chip; drug toxicity; drug metabolism organ-on-a-chip; drug toxicity; drug metabolism
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MDPI and ACS Style

Cong, Y.; Han, X.; Wang, Y.; Chen, Z.; Lu, Y.; Liu, T.; Wu, Z.; Jin, Y.; Luo, Y.; Zhang, X. Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review. Micromachines 2020, 11, 381.

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