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Microfluidic Systems Applied in Solid-State Nanopore Sensors

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
Authors to whom correspondence should be addressed.
Micromachines 2020, 11(3), 332;
Received: 19 February 2020 / Revised: 8 March 2020 / Accepted: 20 March 2020 / Published: 23 March 2020
(This article belongs to the Special Issue Biomedical Microfluidic Devices 2019)
Microfluidic system, as a kind of miniature integrated operating platform, has been applied to solid-state nanopore sensors after many years of experimental study. In the process of introducing microfluidic into solid-state nanopore sensors, many novel device structures are designed due to the abundance of analytes and the diversity of detection methods. Here we review the fundamental setup of nanopore-based microfluidic systems and the developments and advancements that have been taking place in the field. The microfluidic systems with a multichannel strategy to elevate the throughput and efficiency of nanopore sensors are then presented. Multifunctional detection represented by optical-electrical detection, which is realized by microfluidic integration, is also described. A high integration microfluidic system with nanopore is further discussed, which shows the prototype of commercialization. View Full-Text
Keywords: solid-state nanopore; microfluidic system; multichannel; optical detection; integration solid-state nanopore; microfluidic system; multichannel; optical detection; integration
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Fu, J.; Wu, L.; Qiao, Y.; Tu, J.; Lu, Z. Microfluidic Systems Applied in Solid-State Nanopore Sensors. Micromachines 2020, 11, 332.

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