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Molecular Epidemiology of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus in the Ovine Dairy Chain and in Farm-Related Humans

Virulence Genes of S. aureus from Dairy Cow Mastitis and Contagiousness Risk

Department of Veterinary Medicine, University of Milan, Via Celoria 10, 20133 Milan, Italy
Italian Breeders Association (A.I.A.), via Tomassetti 9, 00161 Rome, Italy
Alere Technologies GmbH, Löbstedter Str. 103-105, 07749 Jena, Germany
InfectoGnostics Research Campus, Philosophenweg 7, 07743 Jena, Germany
Institute for Medical Microbiology and Hygiene (IMMH), Technische Universität Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany
Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna-IZSLER, via Einstein, 26900 Lodi, Italy
Author to whom correspondence should be addressed.
Academic Editor: Andreas Rummel
Toxins 2017, 9(6), 195;
Received: 25 May 2017 / Revised: 16 June 2017 / Accepted: 19 June 2017 / Published: 21 June 2017
(This article belongs to the Collection Staphylococcus aureus Toxins)
Staphylococcus aureus (S. aureus) is a major agent of dairy cow intramammary infections: the different prevalences of mastitis reported might be related to a combination of S. aureus virulence factors beyond host factors. The present study considered 169 isolates from different Italian dairy herds that were classified into four groups based on the prevalence of S. aureus infection at the first testing: low prevalence (LP), medium–low (MLP), medium–high (MHP) and high (HP). We aimed to correlate the presence of virulence genes with the prevalence of intramammary infections in order to develop new strategies for the control of S. aureus mastitis. Microarray data were statistically evaluated using binary logistic regression and correspondence analysis to screen the risk factors and the relationship between prevalence group and gene. The analysis showed: (1) 24 genes at significant risk of being detected in all the herds with infection prevalence >5%, including genes belonging to microbial surface components recognizing adhesive matrix molecules (MSCRAMMs), immune evasion and serine proteases; and (2) a significant correlation coefficient between the genes interacting with the host immune response and HP isolates against LP ones. These results support the hypothesis that virulence factors, in addition to cow management, could be related to strain contagiousness, offering new insights into vaccine development. View Full-Text
Keywords: mastitis; dairy cow; S. aureus; virulence genes; microarray; prevalence mastitis; dairy cow; S. aureus; virulence genes; microarray; prevalence
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MDPI and ACS Style

Magro, G.; Biffani, S.; Minozzi, G.; Ehricht, R.; Monecke, S.; Luini, M.; Piccinini, R. Virulence Genes of S. aureus from Dairy Cow Mastitis and Contagiousness Risk. Toxins 2017, 9, 195.

AMA Style

Magro G, Biffani S, Minozzi G, Ehricht R, Monecke S, Luini M, Piccinini R. Virulence Genes of S. aureus from Dairy Cow Mastitis and Contagiousness Risk. Toxins. 2017; 9(6):195.

Chicago/Turabian Style

Magro, Giada, Stefano Biffani, Giulietta Minozzi, Ralf Ehricht, Stefan Monecke, Mario Luini, and Renata Piccinini. 2017. "Virulence Genes of S. aureus from Dairy Cow Mastitis and Contagiousness Risk" Toxins 9, no. 6: 195.

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