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Review

Therapeutic Potential of Cholera Toxin B Subunit for the Treatment of Inflammatory Diseases of the Mucosa

by 1,2,3 and 1,2,3,*
1
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
2
Center for Predictive Medicine, University of Louisville, Louisville, KY 40202, USA
3
James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Steve Peigneur
Toxins 2017, 9(12), 379; https://doi.org/10.3390/toxins9120379
Received: 18 October 2017 / Revised: 14 November 2017 / Accepted: 21 November 2017 / Published: 23 November 2017
(This article belongs to the Special Issue Toxins in Drug Discovery and Pharmacology)
Cholera toxin B subunit (CTB) is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Furthermore, we recently found that a variant of CTB could induce colon epithelial wound healing in mouse colitis models. This review summarizes the possible mechanisms behind CTB’s anti-inflammatory activity and discuss how the protein could impact mucosal inflammatory disease treatment. View Full-Text
Keywords: cholera toxin B subunit; mucosal immunity; immunomodulation; anti-inflammatory; retrograde trafficking; GM1 ganglioside cholera toxin B subunit; mucosal immunity; immunomodulation; anti-inflammatory; retrograde trafficking; GM1 ganglioside
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MDPI and ACS Style

Royal, J.M.; Matoba, N. Therapeutic Potential of Cholera Toxin B Subunit for the Treatment of Inflammatory Diseases of the Mucosa. Toxins 2017, 9, 379. https://doi.org/10.3390/toxins9120379

AMA Style

Royal JM, Matoba N. Therapeutic Potential of Cholera Toxin B Subunit for the Treatment of Inflammatory Diseases of the Mucosa. Toxins. 2017; 9(12):379. https://doi.org/10.3390/toxins9120379

Chicago/Turabian Style

Royal, Joshua M., and Nobuyuki Matoba. 2017. "Therapeutic Potential of Cholera Toxin B Subunit for the Treatment of Inflammatory Diseases of the Mucosa" Toxins 9, no. 12: 379. https://doi.org/10.3390/toxins9120379

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