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Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis

Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, New Taipei City 220, Taiwan
Department of Urology, National Taiwan University Hospital, Taipei 100, Taiwan
Department of Medicine-Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Author to whom correspondence should be addressed.
Present address: Graduate Program in Biomedical Informatics, College of Informatics, Yuan-Ze University, Chung-Li 320, Taiwan
Academic Editor: Hann-Chorng Kuo
Toxins 2016, 8(7), 201;
Received: 31 January 2016 / Revised: 24 June 2016 / Accepted: 28 June 2016 / Published: 1 July 2016
(This article belongs to the Special Issue Botulinum Toxin A on Lower Urinary Tract Dysfunction)
PDF [204 KB, uploaded 1 July 2016]


Botulinum neurotoxin A (BoNT-A), derived from Clostridium botulinum, has been used clinically for several diseases or syndrome including chronic migraine, spasticity, focal dystonia and other neuropathic pain. Chronic pelvic or bladder pain is the one of the core symptoms of bladder pain syndrome/interstitial cystitis (BPS/IC). However, in the field of urology, chronic bladder or pelvic pain is often difficult to eradicate by oral medications or bladder instillation therapy. We are looking for new treatment modality to improve bladder pain or associated urinary symptoms such as frequency and urgency for patients with BPS/IC. Recent studies investigating the mechanism of the antinociceptive effects of BoNT A suggest that it can inhibit the release of peripheral neurotransmitters and inflammatory mediators from sensory nerves. In this review, we will examine the evidence supporting the use of BoNTs in bladder pain from basic science models and review the clinical studies on therapeutic applications of BoNT for BPS/IC. View Full-Text
Keywords: cystitis; botulinum toxin A; interstitial cystitis; intravesical injection cystitis; botulinum toxin A; interstitial cystitis; intravesical injection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chiu, B.; Tai, H.-C.; Chung, S.-D.; Birder, L.A. Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis. Toxins 2016, 8, 201.

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