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Toxins 2016, 8(6), 181;

Use of VacA as a Vaccine Antigen

Service of Gastroenterology and Hepatology, Department of Medicine, Lausanne University Hospital, CLE D203, CHUV, 155 Chemin des Boveresses, CH-1066 Epalinges, Switzerland
Present address: Swiss Federal Institute of Technology, Lausanne, Station 19, CH-1015 Lausanne, Switzerland
Author to whom correspondence should be addressed.
Academic Editor: Timothy L. Cover
Received: 22 March 2016 / Revised: 31 May 2016 / Accepted: 2 June 2016 / Published: 8 June 2016
(This article belongs to the Special Issue Vacuolating Toxin)
Full-Text   |   PDF [226 KB, uploaded 8 June 2016]


One of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of “vacuole”-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis, blockade of T cell proliferation and promotion of regulatory T cells, thereby making it a promising vaccine target. Immunity to bacterial virulence factors is well known to protect humans against bacterial infections; hence, detoxified VacA has been evaluated as a vaccine antigen. Our short review summarizes the pre-clinical and clinical data that have been published on the use of VacA in the development of the H. pylori vaccine. View Full-Text
Keywords: VacA; vaccine; H. pylori VacA; vaccine; H. pylori
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Moyat, M.; Velin, D. Use of VacA as a Vaccine Antigen. Toxins 2016, 8, 181.

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