Next Article in Journal
Use of Monoclonal Antibodies in the Sensitive Detection and Neutralization of Botulinum Neurotoxin Serotype B
Next Article in Special Issue
A Venom Gland Extracellular Chitin-Binding-Like Protein from Pupal Endoparasitoid Wasps, Pteromalus Puparum, Selectively Binds Chitin
Previous Article in Journal
Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test
Previous Article in Special Issue
Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications

Recent Advances in Research on Widow Spider Venoms and Toxins

Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha 410081, China
Author to whom correspondence should be addressed.
Academic Editors: Richard J. Lewis and Glenn F. King
Toxins 2015, 7(12), 5055-5067;
Received: 2 August 2015 / Revised: 2 November 2015 / Accepted: 16 November 2015 / Published: 27 November 2015
(This article belongs to the Special Issue Arthropod Venoms)
Widow spiders have received much attention due to the frequently reported human and animal injures caused by them. Elucidation of the molecular composition and action mechanism of the venoms and toxins has vast implications in the treatment of latrodectism and in the neurobiology and pharmaceutical research. In recent years, the studies of the widow spider venoms and the venom toxins, particularly the α-latrotoxin, have achieved many new advances; however, the mechanism of action of the venom toxins has not been completely clear. The widow spider is different from many other venomous animals in that it has toxic components not only in the venom glands but also in other parts of the adult spider body, newborn spiderlings, and even the eggs. More recently, the molecular basis for the toxicity outside the venom glands has been systematically investigated, with four proteinaceous toxic components being purified and preliminarily characterized, which has expanded our understanding of the widow spider toxins. This review presents a glance at the recent advances in the study on the venoms and toxins from the Latrodectus species. View Full-Text
Keywords: widow spider; venom; toxin; latrotoxin; latroeggtoxin; advance widow spider; venom; toxin; latrotoxin; latroeggtoxin; advance
Show Figures

Graphical abstract

MDPI and ACS Style

Yan, S.; Wang, X. Recent Advances in Research on Widow Spider Venoms and Toxins. Toxins 2015, 7, 5055-5067.

AMA Style

Yan S, Wang X. Recent Advances in Research on Widow Spider Venoms and Toxins. Toxins. 2015; 7(12):5055-5067.

Chicago/Turabian Style

Yan, Shuai, and Xianchun Wang. 2015. "Recent Advances in Research on Widow Spider Venoms and Toxins" Toxins 7, no. 12: 5055-5067.

Find Other Styles

Article Access Map by Country/Region

Back to TopTop