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The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases

Department of Therapeutic Research and Medicines Evaluation, Superior Health Institute, viale Regina Elena 299, Rome 00161, Italy
Author to whom correspondence should be addressed.
Toxins 2014, 6(1), 270-282;
Received: 31 October 2013 / Revised: 17 December 2013 / Accepted: 31 December 2013 / Published: 7 January 2014
(This article belongs to the Special Issue Cytotoxic Necrotizing Factors)
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The Cytotoxic Necrotizing Factor 1 (CNF1), a protein toxin from pathogenic E. coli, modulates the Rho GTPases, thus, directing the organization of the actin cytoskeleton. In the nervous system, the Rho GTPases play a key role in several processes, controlling the morphogenesis of dendritic spines and synaptic plasticity in brain tissues. This review is focused on the peculiar property of CNF1 to enhance brain plasticity in in vivo animal models of central nervous system (CNS) diseases, and on its possible application in therapy. View Full-Text
Keywords: CNF1; actin cytoskeleton; synaptic plasticity; Rho GTPases CNF1; actin cytoskeleton; synaptic plasticity; Rho GTPases

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Travaglione, S.; Loizzo, S.; Ballan, G.; Fiorentini, C.; Fabbri, A. The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases. Toxins 2014, 6, 270-282.

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