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Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype

1
Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
2
Division of Infectious Diseases of the Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
*
Author to whom correspondence should be addressed.
Toxins 2012, 4(6), 430-454; https://doi.org/10.3390/toxins4060430
Received: 29 April 2012 / Revised: 6 June 2012 / Accepted: 7 June 2012 / Published: 11 June 2012
(This article belongs to the Special Issue Toxin-Antibody Interactions)
Antibody therapy remains the only effective treatment for toxin-mediated diseases. The development of hybridoma technology has allowed the isolation of monoclonal antibodies (mAbs) with high specificity and defined properties, and numerous mAbs have been purified and characterized for their protective efficacy against different toxins. This review summarizes the mAb studies for 6 toxins—Shiga toxin, pertussis toxin, anthrax toxin, ricin toxin, botulinum toxin, and Staphylococcal enterotoxin B (SEB)—and analyzes the prevalence of mAb functions and their isotypes. Here we show that most toxin-binding mAbs resulted from immunization are non-protective and that mAbs with potential therapeutic use are preferably characterized. Various common practices and caveats of protection studies are discussed, with the goal of providing insights for the design of future research on antibody-toxin interactions. View Full-Text
Keywords: antibody; neutralization; protection; clearance; vaccine; therapeutics; isotype; animal model; in vivo; disease enhancement antibody; neutralization; protection; clearance; vaccine; therapeutics; isotype; animal model; in vivo; disease enhancement
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Chow, S.-K.; Casadevall, A. Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype. Toxins 2012, 4, 430-454.

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